Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067923733> ?p ?o ?g. }
- W2067923733 endingPage "774" @default.
- W2067923733 startingPage "765" @default.
- W2067923733 abstract "Principal neurons in the hippocampus and prefrontal cortex of the rat have been identified as targets for glucocorticoids involved in the hypothalamic-pituitary-adrenocortical stress response. Alterations in mRNA expression for glucocorticoid receptors in each of these regions have been shown to affect the negative feedback response to corticosterone following an acute stressor. Both decreases in forebrain glucocorticoid receptors and in the efficiency of adrenocortical feedback have been observed in normal aging, and have been selectively induced with experimental lesions or manipulations in neurotransmitter systems. The current study investigated the possibility that a loss of cholinergic support from cells in the basal forebrain, a hallmark of aging, contributes to the selective age-related loss of glucocorticoid receptor mRNA expression at cholinoceptive target sites that include the hippocampus and medial prefrontal cortex. Lesions of the basal forebrain cholinergic system in young adult rats were made by microinjections of the immunotoxin 192 IgG-saporin into the medial septum/vertical limb of the diagonal band and substantia innominata/nucleus basalis. Basal levels of circulating glucocorticoids were unaffected by the lesions. Analysis of both mineralocorticoid and glucocorticoid receptor mRNA expression revealed a significant decrease in glucocorticoid receptor mRNA in the hippocampus and medial prefrontal cortex, with spared expression at subcortical sites and no detectable change in mineralocorticoid receptor mRNA in any of the examined regions. Thus, rats with lesions of the basal forebrain cholinergic system recapitulate some of the detrimental effects of aging associated with glucocorticoid-mediated stress pathways in the brain." @default.
- W2067923733 created "2016-06-24" @default.
- W2067923733 creator A5024183598 @default.
- W2067923733 creator A5028703965 @default.
- W2067923733 creator A5036511886 @default.
- W2067923733 date "2002-12-01" @default.
- W2067923733 modified "2023-09-23" @default.
- W2067923733 title "Effects of cholinergic lesions produced by infusions of 192 IgG-saporin on glucocorticoid receptor mRNA expression in hippocampus and medial prefrontal cortex of the rat" @default.
- W2067923733 cites W1524361670 @default.
- W2067923733 cites W1536396606 @default.
- W2067923733 cites W1547358456 @default.
- W2067923733 cites W1672683865 @default.
- W2067923733 cites W1854670164 @default.
- W2067923733 cites W1920785023 @default.
- W2067923733 cites W1927719697 @default.
- W2067923733 cites W1965382321 @default.
- W2067923733 cites W1968812762 @default.
- W2067923733 cites W1970982006 @default.
- W2067923733 cites W1971117140 @default.
- W2067923733 cites W1971383287 @default.
- W2067923733 cites W1972718612 @default.
- W2067923733 cites W1976510055 @default.
- W2067923733 cites W1979620819 @default.
- W2067923733 cites W1980803306 @default.
- W2067923733 cites W1982446401 @default.
- W2067923733 cites W1983355364 @default.
- W2067923733 cites W1987557547 @default.
- W2067923733 cites W1987780039 @default.
- W2067923733 cites W1987897953 @default.
- W2067923733 cites W1989256353 @default.
- W2067923733 cites W1994067502 @default.
- W2067923733 cites W2001134882 @default.
- W2067923733 cites W2005078651 @default.
- W2067923733 cites W2014212152 @default.
- W2067923733 cites W2015550631 @default.
- W2067923733 cites W2016023867 @default.
- W2067923733 cites W2016773845 @default.
- W2067923733 cites W2021280501 @default.
- W2067923733 cites W2021346798 @default.
- W2067923733 cites W2024573722 @default.
- W2067923733 cites W2031667205 @default.
- W2067923733 cites W2032281246 @default.
- W2067923733 cites W2034879076 @default.
- W2067923733 cites W2037004891 @default.
- W2067923733 cites W2037912694 @default.
- W2067923733 cites W2044191726 @default.
- W2067923733 cites W2045058187 @default.
- W2067923733 cites W2046177214 @default.
- W2067923733 cites W2046397474 @default.
- W2067923733 cites W2051715358 @default.
- W2067923733 cites W2054306224 @default.
- W2067923733 cites W2058266050 @default.
- W2067923733 cites W2059982452 @default.
- W2067923733 cites W2061983017 @default.
- W2067923733 cites W2068982826 @default.
- W2067923733 cites W2072538942 @default.
- W2067923733 cites W2072717295 @default.
- W2067923733 cites W2074802748 @default.
- W2067923733 cites W2076018826 @default.
- W2067923733 cites W2077213641 @default.
- W2067923733 cites W2077677077 @default.
- W2067923733 cites W2079007749 @default.
- W2067923733 cites W2087986775 @default.
- W2067923733 cites W2088219973 @default.
- W2067923733 cites W2090828055 @default.
- W2067923733 cites W2093374391 @default.
- W2067923733 cites W2093496334 @default.
- W2067923733 cites W2093685381 @default.
- W2067923733 cites W2094423328 @default.
- W2067923733 cites W2097075649 @default.
- W2067923733 cites W2104227586 @default.
- W2067923733 cites W2110743747 @default.
- W2067923733 cites W2119125561 @default.
- W2067923733 cites W2119725374 @default.
- W2067923733 cites W2126974689 @default.
- W2067923733 cites W2132492497 @default.
- W2067923733 cites W2134033459 @default.
- W2067923733 cites W2158052449 @default.
- W2067923733 cites W2162943890 @default.
- W2067923733 cites W241168973 @default.
- W2067923733 cites W4230562868 @default.
- W2067923733 cites W4238481893 @default.
- W2067923733 cites W4239267948 @default.
- W2067923733 cites W4256416970 @default.
- W2067923733 cites W4294443837 @default.
- W2067923733 doi "https://doi.org/10.1016/s0306-4522(02)00487-6" @default.
- W2067923733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12435415" @default.
- W2067923733 hasPublicationYear "2002" @default.
- W2067923733 type Work @default.
- W2067923733 sameAs 2067923733 @default.
- W2067923733 citedByCount "30" @default.
- W2067923733 countsByYear W20679237332013 @default.
- W2067923733 countsByYear W20679237332015 @default.
- W2067923733 countsByYear W20679237332017 @default.
- W2067923733 countsByYear W20679237332019 @default.
- W2067923733 crossrefType "journal-article" @default.
- W2067923733 hasAuthorship W2067923733A5024183598 @default.
- W2067923733 hasAuthorship W2067923733A5028703965 @default.