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• W2067943520 startingPage "115" @default.
• W2067943520 abstract "Huntington disease is a neurodegenerative disease with complex pathophysiology. Recently, role of neuroinflammation and interplay between various other cellular cascades have been suggested to be involved in pathophysiology of Huntington disease. Involvement of calcium overload mediated oxidative damage and excitotoxicity have been suggested to play a central role in quinolinic acid induced Huntington like symptoms. The present study has been carried out to investigate the neuroprotective effect of calcium channel blockers (verapamil and diltiazem) against quinolinic acid induced dysfunction in motor, biochemical and neuroinflammatory signaling in rats. Intrastriatal quinolinic acid administration leads to significant motor [locomotor (72% reduction), rotarod (55% reduction), balance beam walk performance] dysfunction coupled with the marked oxidative damage and increased neuroinflammatory markers [TNF-α (140%), IL-6 (115%), caspase-3(75%)] levels in striatum as compared to the sham treatment. Verapamil (10 and 20 mg/kg), diltiazem (10 and 20 mg/kg) drug treatment for 21 days resulted in a significant improvement in the motor function (improvement in locomotor activity, rotarod and balance beam walk performance). Further, verapamil (10 and 20 mg/kg), diltiazem (10 and 20 mg/kg) treatment significantly attenuated oxidative damage, level of proinflammatory mediators (TNF-α IL-6 and caspase-3) in quinolinic acid treated animals. Results of the present study demonstrate that protective effect of these calcium channel blockers (verapamil, diltiazem) might be due to their inhibitory action on different neuroinflammatory pathways against quinolinic acid induced Huntington disease like symptoms in rats." @default.
• W2067943520 created "2016-06-24" @default.
• W2067943520 creator A5020718241 @default.
• W2067943520 creator A5031501378 @default.
• W2067943520 creator A5047004036 @default.
• W2067943520 date "2011-02-01" @default.
• W2067943520 modified "2023-10-18" @default.
• W2067943520 title "Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats" @default.
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• W2067943520 doi "https://doi.org/10.1016/j.brainres.2010.11.060" @default.
• W2067943520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21112316" @default.
• W2067943520 hasPublicationYear "2011" @default.
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