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• W2067944324 endingPage "1884" @default.
• W2067944324 startingPage "1877" @default.
• W2067944324 abstract "The characteristics of the noradrenaline (NA)-sensitive adenylate cyclase in mouse limbic forebrain slices have been examined. The order of potency (EC 50 ) found for various adrenergic agonists was l -isoprenaline > l -adrenaline ⩾ l -NA which corresponds to a β-adrenergic receptor. However, maximal stimulation was greatest for l -adrenaline, and smaller for l -NA and l -isoprenaline. The stimulation produced by l -isoprenaline was non-significantly enhanced by concomitant administration of the α-adrenergic agonists, l -phenylephrine and clonidine, but the stimulation produced by l -NA was not enhanced by l -isoprenaline. Various adrenergic antagonists inhibited the stimulation due to 10 −5 M l -NA with IC 50 values of order of potency phentolamine > phenoxybenzamine > d . l -propranolol. However, the maximal inhibition produced by d ,l-propranolol was 95 per cent, whereas that produced by phentolamine was 82 per cent. The results suggest the presence of a population in this region of at least two types of receptor which may be stimulated by l -NA. One has β-adrenergic properties and the other appears to correspond to a β-dependent α-adrenergic receptor. Desipramine also inhibited the NA-sensitive adenylate cyclase, suggesting some dependence of the adenylate cyclase on NA uptake mechanisms. The dopaminergic antagonist pimozide was also found to be a potent inhibitor of NA-sensitive adenylate cyclase with an IC 50 of 1.3 × 10 −7 M and a maximal inhibition at 10 − 6 M of 84 per cent. The effect of dopaminergic agonists was also studied on this system, which is not stimulated by dopamine itself at concentrations up to 1O −4 M. The ergot alkaloids bromocryptine and ergocornine were potent inhibitors of the NA-sensitive adenylate cyclase, bromocryptine having an IC 50 for inhibition of 9.4 × 10 −9 M, similar to that of phentolamine." @default.
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• W2067944324 date "1977-10-01" @default.
• W2067944324 modified "2023-10-14" @default.
• W2067944324 title "Noradrenaline-sensitive adenylate cyclase in slices of mouse limbic forebrain: characterisation and effect of dopaminergic agonists" @default.
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• W2067944324 doi "https://doi.org/10.1016/0006-2952(77)90161-7" @default.
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