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• W2067944993 abstract "ABSTRACT Human African trypanosomiasis (HAT) or sleeping sickness is a neglected disease that affects poor rural populations across sub-Saharan Africa. Confirmation of diagnosis is based on detection of parasites in either blood or lymph by microscopy. Here we present the development and the first-phase evaluation of a simple and rapid test (HAT-PCR-OC [human African trypanosomiasis-PCR-oligochromatography]) for detection of amplified Trypanosoma brucei DNA. PCR products are visualized on a dipstick through hybridization with a gold-conjugated probe (oligochromatography). Visualization is straightforward and takes only 5 min. Controls both for the PCR and for DNA migration are incorporated into the assay. The lower detection limit of the test is 5 fg of pure T. brucei DNA. One parasite in 180 μl of blood is still detectable. Sensitivity and specificity for T. brucei were calculated at 100% when tested on blood samples from 26 confirmed sleeping sickness patients, 18 negative controls (nonendemic region), and 50 negative control blood samples from an endemic region. HAT-PCR-OC is a promising new tool for diagnosis of sleeping sickness in laboratory settings, and the diagnostic format described here may have wider application for other infectious diseases." @default.
• W2067944993 created "2016-06-24" @default.
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• W2067944993 date "2006-08-01" @default.
• W2067944993 modified "2023-10-01" @default.
• W2067944993 title "Molecular Dipstick Test for Diagnosis of Sleeping Sickness" @default.
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• W2067944993 doi "https://doi.org/10.1128/jcm.02594-05" @default.
• W2067944993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1594664" @default.
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