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• W2067947636 abstract "SWAP-70 is a protein involved in actin rearrangement, especially in membrane ruffling. Mouse embryo fibroblasts (MEFs) deficient in SWAP-70 show impaired membrane ruffling and fail to grow in soft agar after transformation by v-Src. Here, we show that v-Src transformed MEFs expressing SWAP-70 are highly invasive. MEFs expressing SWAP-70 or v-Src alone were far less invasive, suggesting that both proteins were required for the cells to be invasive. Expression of both SWAP-70 and v-Src induced constant membrane ruffling, which may cause vigorous cell movement, probably required for invasiveness of the cells. Expression of v-Src alone morphologically transformed MEFs but formed lamellipodia rather than membrane ruffles, suggesting less aggressive nature of the cells compared with those expressing both SWAP-70 and v-Src. These results suggest that v-Src and SWAP-70 act synergistically in the invasion activity of MEFs. © 2008 IUBMB IUBMB Life, 60(4): 236–240, 2008" @default.
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• W2067947636 date "2008-01-01" @default.
• W2067947636 modified "2023-10-16" @default.
• W2067947636 title "SWAP-70 is important for invasive phenotypes of mouse embryo fibroblasts transformed by v-Src" @default.
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• W2067947636 doi "https://doi.org/10.1002/iub.33" @default.
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