FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067971523> ?p ?o ?g. }

• W2067971523 endingPage "1134" @default.
• W2067971523 startingPage "1130" @default.
• W2067971523 abstract "Postsynaptic membranes, rich in the nicotinic acetylcholine receptor, were isolated from the electric organ of Torpedo californica and shown to contain a cAMP-dependent protein kinase and a calcium/calmodulin-dependent protein kinase. The cAMP-dependent protein kinase phosphorylated the γ and δ subunits of the acetylcholine receptor. The phosphorylated subunits were identified after purification of the acetylcholine receptor by affinity chromatography on a choline carboxymethyl affinity gel. In contrast, the calcium/calmodulin-dependent protein kinase phosphorylated proteins that were separated from the acetylcholine receptor by affinity chromatography. Protein kinase inhibitor, a specific inhibitor of the catalytic subunit of cAMP-dependent protein kinase, abolished the basal endogenous phosphorylation of the γ and δ subunits of the receptor. cAMP activation of the endogenous phosphorylation of the γ and δ subunits was dose dependent with a half-maximal response at 25 nM. Studies were also carried out with acetylcholine receptor purified from T. californica and catalytic subunit of cAMP-dependent protein kinase purified from bovine heart. The purified acetylcholine receptor was rapidly and specifically phosphorylated on the γ and δ subunits by the purified catalytic subunit of cAMP-dependent protein kinase to a stoichiometry of 1.0 and 0.89 mol of 32 P per mol of receptor, respectively. The initial rates of phosphorylation of the γ and δ subunits of the receptor were comparable to those of histone f2B and synapsin I (protein I), two of the most effective substrates for the catalytic subunit. Under the conditions used, the γ and δ subunits had K m values of 4.0 and 3.3 μM and V max values of 2.7 and 2.1 μmol/min per mg, respectively. The results are consistent with the idea that the acetylcholine receptor is phosphorylated in vivo by a cAMP-dependent protein kinase." @default.
• W2067971523 created "2016-06-24" @default.
• W2067971523 creator A5052825834 @default.
• W2067971523 creator A5065713713 @default.
• W2067971523 date "1983-02-01" @default.
• W2067971523 modified "2023-10-18" @default.
• W2067971523 title "cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor" @default.
• W2067971523 cites W1509118314 @default.
• W2067971523 cites W1527438907 @default.
• W2067971523 cites W1527467938 @default.
• W2067971523 cites W1558807267 @default.
• W2067971523 cites W1569489894 @default.
• W2067971523 cites W1775749144 @default.
• W2067971523 cites W1964800013 @default.
• W2067971523 cites W1966856450 @default.
• W2067971523 cites W1967416683 @default.
• W2067971523 cites W1968716689 @default.
• W2067971523 cites W1971742213 @default.
• W2067971523 cites W1971880089 @default.
• W2067971523 cites W1977680327 @default.
• W2067971523 cites W1983731986 @default.
• W2067971523 cites W1984059468 @default.
• W2067971523 cites W1987115674 @default.
• W2067971523 cites W1994206549 @default.
• W2067971523 cites W1994231412 @default.
• W2067971523 cites W1998132488 @default.
• W2067971523 cites W2010005988 @default.
• W2067971523 cites W2018117360 @default.
• W2067971523 cites W2018289835 @default.
• W2067971523 cites W2023916700 @default.
• W2067971523 cites W2024990200 @default.
• W2067971523 cites W2028298986 @default.
• W2067971523 cites W2031245298 @default.
• W2067971523 cites W2055415506 @default.
• W2067971523 cites W2059256408 @default.
• W2067971523 cites W2067562301 @default.
• W2067971523 cites W2089093048 @default.
• W2067971523 cites W2091707282 @default.
• W2067971523 cites W2100837269 @default.
• W2067971523 cites W2102131116 @default.
• W2067971523 cites W2130540953 @default.
• W2067971523 cites W2158195565 @default.
• W2067971523 cites W2745552089 @default.
• W2067971523 cites W38484849 @default.
• W2067971523 cites W84630131 @default.
• W2067971523 doi "https://doi.org/10.1073/pnas.80.4.1130" @default.
• W2067971523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/393542" @default.
• W2067971523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6302672" @default.
• W2067971523 hasPublicationYear "1983" @default.
• W2067971523 type Work @default.
• W2067971523 sameAs 2067971523 @default.
• W2067971523 citedByCount "165" @default.
• W2067971523 countsByYear W20679715232012 @default.
• W2067971523 countsByYear W20679715232014 @default.
• W2067971523 countsByYear W20679715232021 @default.
• W2067971523 countsByYear W20679715232023 @default.
• W2067971523 crossrefType "journal-article" @default.
• W2067971523 hasAuthorship W2067971523A5052825834 @default.
• W2067971523 hasAuthorship W2067971523A5065713713 @default.
• W2067971523 hasBestOaLocation W20679715232 @default.
• W2067971523 hasConcept C116289061 @default.
• W2067971523 hasConcept C11960822 @default.
• W2067971523 hasConcept C153911025 @default.
• W2067971523 hasConcept C170493617 @default.
• W2067971523 hasConcept C185592680 @default.
• W2067971523 hasConcept C55493867 @default.
• W2067971523 hasConcept C64615621 @default.
• W2067971523 hasConcept C80161118 @default.
• W2067971523 hasConcept C86803240 @default.
• W2067971523 hasConcept C97029542 @default.
• W2067971523 hasConceptScore W2067971523C116289061 @default.
• W2067971523 hasConceptScore W2067971523C11960822 @default.
• W2067971523 hasConceptScore W2067971523C153911025 @default.
• W2067971523 hasConceptScore W2067971523C170493617 @default.
• W2067971523 hasConceptScore W2067971523C185592680 @default.
• W2067971523 hasConceptScore W2067971523C55493867 @default.
• W2067971523 hasConceptScore W2067971523C64615621 @default.
• W2067971523 hasConceptScore W2067971523C80161118 @default.
• W2067971523 hasConceptScore W2067971523C86803240 @default.
• W2067971523 hasConceptScore W2067971523C97029542 @default.
• W2067971523 hasIssue "4" @default.
• W2067971523 hasLocation W20679715231 @default.
• W2067971523 hasLocation W20679715232 @default.
• W2067971523 hasLocation W20679715233 @default.
• W2067971523 hasLocation W20679715234 @default.
• W2067971523 hasOpenAccess W2067971523 @default.
• W2067971523 hasPrimaryLocation W20679715231 @default.
• W2067971523 hasRelatedWork W1829993289 @default.
• W2067971523 hasRelatedWork W2037796657 @default.
• W2067971523 hasRelatedWork W2048725786 @default.
• W2067971523 hasRelatedWork W2067808461 @default.
• W2067971523 hasRelatedWork W2085199043 @default.
• W2067971523 hasRelatedWork W2087893167 @default.
• W2067971523 hasRelatedWork W2128039605 @default.
• W2067971523 hasRelatedWork W2169644275 @default.
• W2067971523 hasRelatedWork W2481894811 @default.
• W2067971523 hasRelatedWork W2136545008 @default.
• W2067971523 hasVolume "80" @default.

• next