Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067972848> ?p ?o ?g. }
- W2067972848 endingPage "1665" @default.
- W2067972848 startingPage "1653" @default.
- W2067972848 abstract "Our previous studies have shown that cyclovirobuxine D (CVB-D) ameliorated the cardiac function in heart failure rats. Considering the relationship between cardiac function and [Ca2 +]i, and the role of calcium cycling on regulating [Ca2 +]i, the present study was designed to evaluate the influence of CVB-D on the calcium transient of myocytes from neonatal rats and adult heart failure (HF) rats. The expression of calcium cycling proteins, including L-type calcium channel (LTCC), ryanodine receptor 2 (RYR2), sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) and sodium–calcium exchanger (NCX), were investigated to explore the underlying mechanism. CVB-D increased the intensity of calcium transient, accelerated the process of calcium transient and attenuation in the neonatal and adult myocytes. Furthermore, CVB-D shortened Tpeak and Tattenuation in the adult myocytes and slowed down the heart rate of neonatal myocytes. Besides, CVB-D increased the expression of RYR2 and SERCA2a, decreased the expression of NCX, but showed no significant effect on LTCC. Thus, it was concluded that CVB-D increased the release and uptake of Ca2 + in systolic and diastolic period, respectively. CVB-D might not only facilitate the utilization of intracellular Ca2 +, but also prevent the loss of Ca2 +." @default.
- W2067972848 created "2016-06-24" @default.
- W2067972848 creator A5002130552 @default.
- W2067972848 creator A5012003921 @default.
- W2067972848 creator A5016434083 @default.
- W2067972848 creator A5054175249 @default.
- W2067972848 creator A5086371314 @default.
- W2067972848 date "2012-12-01" @default.
- W2067972848 modified "2023-09-27" @default.
- W2067972848 title "Influence of cyclovirobuxine D on intracellular [Ca2+] regulation and the expression of the calcium cycling proteins in rat myocytes" @default.
- W2067972848 cites W1505226241 @default.
- W2067972848 cites W1509313017 @default.
- W2067972848 cites W1968936969 @default.
- W2067972848 cites W1991806248 @default.
- W2067972848 cites W2002459835 @default.
- W2067972848 cites W2004733118 @default.
- W2067972848 cites W2008426127 @default.
- W2067972848 cites W2040543880 @default.
- W2067972848 cites W2044293270 @default.
- W2067972848 cites W2049592653 @default.
- W2067972848 cites W2054444865 @default.
- W2067972848 cites W2055123579 @default.
- W2067972848 cites W2059970806 @default.
- W2067972848 cites W2060019114 @default.
- W2067972848 cites W2060727804 @default.
- W2067972848 cites W2062026598 @default.
- W2067972848 cites W2064113230 @default.
- W2067972848 cites W2065902608 @default.
- W2067972848 cites W2068613600 @default.
- W2067972848 cites W2070081373 @default.
- W2067972848 cites W2070504091 @default.
- W2067972848 cites W2076116129 @default.
- W2067972848 cites W2076739605 @default.
- W2067972848 cites W2080370918 @default.
- W2067972848 cites W2090502913 @default.
- W2067972848 cites W2091811857 @default.
- W2067972848 cites W2098834360 @default.
- W2067972848 cites W2100183270 @default.
- W2067972848 cites W2107992067 @default.
- W2067972848 cites W2111523164 @default.
- W2067972848 cites W2130377813 @default.
- W2067972848 cites W2133349278 @default.
- W2067972848 cites W2138783312 @default.
- W2067972848 cites W2141297049 @default.
- W2067972848 cites W2147372693 @default.
- W2067972848 cites W2162409114 @default.
- W2067972848 cites W2164624818 @default.
- W2067972848 cites W2168088180 @default.
- W2067972848 cites W4210336424 @default.
- W2067972848 cites W4253283232 @default.
- W2067972848 doi "https://doi.org/10.1016/j.fitote.2012.09.019" @default.
- W2067972848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23022536" @default.
- W2067972848 hasPublicationYear "2012" @default.
- W2067972848 type Work @default.
- W2067972848 sameAs 2067972848 @default.
- W2067972848 citedByCount "12" @default.
- W2067972848 countsByYear W20679728482014 @default.
- W2067972848 countsByYear W20679728482015 @default.
- W2067972848 countsByYear W20679728482016 @default.
- W2067972848 countsByYear W20679728482020 @default.
- W2067972848 countsByYear W20679728482021 @default.
- W2067972848 countsByYear W20679728482022 @default.
- W2067972848 countsByYear W20679728482023 @default.
- W2067972848 crossrefType "journal-article" @default.
- W2067972848 hasAuthorship W2067972848A5002130552 @default.
- W2067972848 hasAuthorship W2067972848A5012003921 @default.
- W2067972848 hasAuthorship W2067972848A5016434083 @default.
- W2067972848 hasAuthorship W2067972848A5054175249 @default.
- W2067972848 hasAuthorship W2067972848A5086371314 @default.
- W2067972848 hasConcept C113217602 @default.
- W2067972848 hasConcept C126322002 @default.
- W2067972848 hasConcept C134018914 @default.
- W2067972848 hasConcept C158617107 @default.
- W2067972848 hasConcept C181080969 @default.
- W2067972848 hasConcept C185592680 @default.
- W2067972848 hasConcept C190712762 @default.
- W2067972848 hasConcept C207200792 @default.
- W2067972848 hasConcept C2777735026 @default.
- W2067972848 hasConcept C519063684 @default.
- W2067972848 hasConcept C55493867 @default.
- W2067972848 hasConcept C71924100 @default.
- W2067972848 hasConcept C79879829 @default.
- W2067972848 hasConcept C87975464 @default.
- W2067972848 hasConceptScore W2067972848C113217602 @default.
- W2067972848 hasConceptScore W2067972848C126322002 @default.
- W2067972848 hasConceptScore W2067972848C134018914 @default.
- W2067972848 hasConceptScore W2067972848C158617107 @default.
- W2067972848 hasConceptScore W2067972848C181080969 @default.
- W2067972848 hasConceptScore W2067972848C185592680 @default.
- W2067972848 hasConceptScore W2067972848C190712762 @default.
- W2067972848 hasConceptScore W2067972848C207200792 @default.
- W2067972848 hasConceptScore W2067972848C2777735026 @default.
- W2067972848 hasConceptScore W2067972848C519063684 @default.
- W2067972848 hasConceptScore W2067972848C55493867 @default.
- W2067972848 hasConceptScore W2067972848C71924100 @default.
- W2067972848 hasConceptScore W2067972848C79879829 @default.
- W2067972848 hasConceptScore W2067972848C87975464 @default.
- W2067972848 hasIssue "8" @default.