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• W2067980818 abstract "Evidence that ACTH has an effect on behavior that is independent of its effects on the adrenals is reviewed. Results of experiments with rats indicate that ACTH4–10 and other fragments or analogs that are devoid of endocrine effects have an effect on acquisition and delay extinction of conditioned behavior. ACTH4–10 has a facilitating effect on retrieval from memory. This is shown to be independent of the type of test design used to evaluate retrieval. It is suggested that ACTH activates the reticulolimbic circuits, which may result in increased motivation or attention. Safety studies in rats and dogs did not reveal any adverse effects of chronic treatment with very high dosages of ACTH4–10. The results of the first studies of ACTH4–10 (Org OI 63) in man are discussed and interpreted to indicate that ACTH4–10 probably improves attentional processes, including retrieval functions, and that further evaluation of ACTH-like peptides is justified." @default.
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• W2067980818 date "1977-07-01" @default.
• W2067980818 modified "2023-09-26" @default.
• W2067980818 title "Possible significance of ACTH fragments for human mental performance" @default.
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• W2067980818 doi "https://doi.org/10.1016/s0091-6773(77)90876-8" @default.
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