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- W2067985686 abstract "The anti-arrhythmic action of 2,3-cis-1,2,3,4-tetrahydro-5-[(2-hydroxy-3-tert-butylamino)propoxy]2,3-naphthalenediol (nadolol) was evaluated and compared with that of propranolol in several experimental models of cardiac arrhythmias. Both nadolol and propranolol antagonized isoproterenol-induced tachycardia and ouabain- induced arrhythmias in cats, antagonized coronary artery ligation-induced ventricular fibrillation and suppressed ventricular ectopic activity during vagal stimulation in dogs. In contrast to propranolol, nadolol was considerably weaker in suppressing existing digoxin-induced arrhythmias, lacked local anesthetic activity and did not depress the heart in dogs. Because of these findings, it is concluded that the anti-arrhythmic activity of nadolol is apparently related to blockade of β-adrenergic receptors." @default.
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- W2067985686 date "1976-01-01" @default.
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- W2067985686 title "Anti-arrhythmic action of nadolol, a β-adrenergic receptor blocking agent" @default.
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- W2067985686 doi "https://doi.org/10.1016/0014-2999(76)90296-x" @default.
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