Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067989987> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2067989987 endingPage "519" @default.
- W2067989987 startingPage "516" @default.
- W2067989987 abstract "The protective effect of fleroxacin on isepamicin-induced nephrotoxicity was investigated. Wistar rats were administered either fleroxacin 100 mg/kg orally, isepamicin 300 mg/kg subcutaneously, or fleroxacin and isepamicin in combination for 14 d. The animals given 300 mg/kg of isepamicin showed a significant increase in urine N-acetyl-beta-D-glucosaminidase (NAG) levels as compared with the control animals which received saline (p<0.01). However, the increase in NAG level was markedly less when isepamicin was administered in combination with fleroxacin (p<0.01). Fleroxacin alone had no effect on urine NAG activity. Serum creatinine and blood urea nitrogen (BUN) levels were significantly higher in animals treated with isepamicin alone than in the control animals (p<0.01) or animals receiving the isepamicin fleroxacin combination (p<0.01). Histopathologically, fleroxacin induced very few cellular alterations, but considerably reduced the manifestation of typical signs of isepamicin nephrotoxicity. This investigation demonstrates that fleroxacin protects animals against isepamicin-induced nephrotoxicity." @default.
- W2067989987 created "2016-06-24" @default.
- W2067989987 creator A5000226401 @default.
- W2067989987 creator A5002228837 @default.
- W2067989987 creator A5010911127 @default.
- W2067989987 creator A5031566556 @default.
- W2067989987 creator A5057807960 @default.
- W2067989987 date "2002-01-01" @default.
- W2067989987 modified "2023-10-16" @default.
- W2067989987 title "Protective Effect of Fleroxacin against the Nephrotoxicity of Isepamicin in Rats" @default.
- W2067989987 cites W1968141604 @default.
- W2067989987 cites W1973439187 @default.
- W2067989987 cites W1977038581 @default.
- W2067989987 cites W1981375683 @default.
- W2067989987 cites W1984854014 @default.
- W2067989987 cites W1987863950 @default.
- W2067989987 cites W2019971500 @default.
- W2067989987 cites W2025127984 @default.
- W2067989987 cites W2040546862 @default.
- W2067989987 cites W2047051639 @default.
- W2067989987 cites W2049650125 @default.
- W2067989987 cites W2073841067 @default.
- W2067989987 cites W2086169107 @default.
- W2067989987 cites W2089391907 @default.
- W2067989987 cites W2094743922 @default.
- W2067989987 cites W2106293229 @default.
- W2067989987 cites W2262765979 @default.
- W2067989987 cites W2414702330 @default.
- W2067989987 cites W2061159828 @default.
- W2067989987 doi "https://doi.org/10.1248/bpb.25.516" @default.
- W2067989987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11995935" @default.
- W2067989987 hasPublicationYear "2002" @default.
- W2067989987 type Work @default.
- W2067989987 sameAs 2067989987 @default.
- W2067989987 citedByCount "11" @default.
- W2067989987 countsByYear W20679899872018 @default.
- W2067989987 crossrefType "journal-article" @default.
- W2067989987 hasAuthorship W2067989987A5000226401 @default.
- W2067989987 hasAuthorship W2067989987A5002228837 @default.
- W2067989987 hasAuthorship W2067989987A5010911127 @default.
- W2067989987 hasAuthorship W2067989987A5031566556 @default.
- W2067989987 hasAuthorship W2067989987A5057807960 @default.
- W2067989987 hasBestOaLocation W20679899871 @default.
- W2067989987 hasConcept C126189478 @default.
- W2067989987 hasConcept C126322002 @default.
- W2067989987 hasConcept C185592680 @default.
- W2067989987 hasConcept C2777316974 @default.
- W2067989987 hasConcept C2778049240 @default.
- W2067989987 hasConcept C2778512257 @default.
- W2067989987 hasConcept C2780026642 @default.
- W2067989987 hasConcept C2780091579 @default.
- W2067989987 hasConcept C2780306776 @default.
- W2067989987 hasConcept C3019249092 @default.
- W2067989987 hasConcept C501593827 @default.
- W2067989987 hasConcept C55493867 @default.
- W2067989987 hasConcept C71924100 @default.
- W2067989987 hasConcept C98274493 @default.
- W2067989987 hasConceptScore W2067989987C126189478 @default.
- W2067989987 hasConceptScore W2067989987C126322002 @default.
- W2067989987 hasConceptScore W2067989987C185592680 @default.
- W2067989987 hasConceptScore W2067989987C2777316974 @default.
- W2067989987 hasConceptScore W2067989987C2778049240 @default.
- W2067989987 hasConceptScore W2067989987C2778512257 @default.
- W2067989987 hasConceptScore W2067989987C2780026642 @default.
- W2067989987 hasConceptScore W2067989987C2780091579 @default.
- W2067989987 hasConceptScore W2067989987C2780306776 @default.
- W2067989987 hasConceptScore W2067989987C3019249092 @default.
- W2067989987 hasConceptScore W2067989987C501593827 @default.
- W2067989987 hasConceptScore W2067989987C55493867 @default.
- W2067989987 hasConceptScore W2067989987C71924100 @default.
- W2067989987 hasConceptScore W2067989987C98274493 @default.
- W2067989987 hasIssue "4" @default.
- W2067989987 hasLocation W20679899871 @default.
- W2067989987 hasLocation W20679899872 @default.
- W2067989987 hasOpenAccess W2067989987 @default.
- W2067989987 hasPrimaryLocation W20679899871 @default.
- W2067989987 hasRelatedWork W182688032 @default.
- W2067989987 hasRelatedWork W1979610724 @default.
- W2067989987 hasRelatedWork W2106188053 @default.
- W2067989987 hasRelatedWork W2117825355 @default.
- W2067989987 hasRelatedWork W2155342874 @default.
- W2067989987 hasRelatedWork W2417922727 @default.
- W2067989987 hasRelatedWork W2437428354 @default.
- W2067989987 hasRelatedWork W2502257454 @default.
- W2067989987 hasRelatedWork W3025255853 @default.
- W2067989987 hasRelatedWork W4214585610 @default.
- W2067989987 hasVolume "25" @default.
- W2067989987 isParatext "false" @default.
- W2067989987 isRetracted "false" @default.
- W2067989987 magId "2067989987" @default.
- W2067989987 workType "article" @default.