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- W2067993088 abstract "To define the effects of adrenocorticotropic hormone (ACTH) in immunocompetent cells, ion channel activities in cultured mouse peritoneal macrophages were analyzed by the perforated patch-clamp method. ACTH induced outward currents at smaller holding potentials than K+ equilibrium potentials. Reversal potentials of ACTH-induced currents were dependent on external K+ concentrations, but not on external Cl- concentration. Quinine potently blocked the outward current and tetraethylammonium (TEA) partially suppressed that current. ACTH did not induce the response in Ca2+ free solution containing EGTA. These results suggest that ACTH can modulate macrophage functions through the activation of Ca2+ dependent K+ channels." @default.
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- W2067993088 date "2001-02-01" @default.
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- W2067993088 title "Adrenocorticotropic hormone activates an outward current in cultured mouse peritoneal macrophages" @default.
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- W2067993088 doi "https://doi.org/10.1016/s0165-5728(00)00442-2" @default.
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