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• W2067994518 abstract "Abstract Background Zebrafish embryos are transcriptionally silent until activation of the zygotic genome during the 10 th cell cycle. Onset of transcription is followed by cellular and morphological changes involving cell speciation and gastrulation. Previous genome-wide surveys of transcriptional changes only assessed gene expression levels; however, recent studies have shown the necessity to map isoform-specific transcriptional changes. Here, we perform isoform discovery and quantification on transcriptome sequences from before and after zebrafish zygotic genome activation (ZGA). Results We identify novel isoforms and isoform switches during ZGA for genes related to cell adhesion, pluripotency and DNA methylation. Isoform switching events include alternative splicing and changes in transcriptional start sites and in 3’ untranslated regions. New isoforms are identified even for well-characterized genes such as pou5f1 , sall4 and dnmt1 . Genes involved in cell-cell interactions such as f11r and magi1 display isoform switches with alterations of coding sequences. We also detect over 1000 transcripts that acquire a longer 3’ terminal exon when transcribed by the zygote compared to their maternal transcript counterparts. ChIP-sequencing data mapped onto skipped exon events reveal a correlation between histone H3K36 trimethylation peaks and skipped exons, suggesting epigenetic marks being part of alternative splicing regulation. Conclusions The novel isoforms and isoform switches reported here include regulators of transcriptional, cellular and morphological changes taking place around ZGA. Our data display an array of isoform-related functional changes and represent a valuable resource complementary to existing early embryo transcriptomes." @default.
• W2067994518 created "2016-06-24" @default.
• W2067994518 creator A5027164670 @default.
• W2067994518 creator A5030344953 @default.
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• W2067994518 creator A5064975863 @default.
• W2067994518 creator A5072506531 @default.
• W2067994518 creator A5090129454 @default.
• W2067994518 date "2013-05-15" @default.
• W2067994518 modified "2023-10-18" @default.
• W2067994518 title "Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish" @default.
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• W2067994518 doi "https://doi.org/10.1186/1471-2164-14-331" @default.
• W2067994518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3747860" @default.
• W2067994518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23676078" @default.

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