Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067996909> ?p ?o ?g. }
- W2067996909 endingPage "132" @default.
- W2067996909 startingPage "127" @default.
- W2067996909 abstract "The uptake and release of [3H]norepinephrine [( 3H]NE) were investigated using isolated rat globus pallidus slices to determine the possible neurotransmitter role of this catecholamine. The uptake into these slices was linear for the first 10 min. Kinetic analysis indicated two components of NE accumulation, one representing a high (Km1 2.9 X 10(-7) M and Vmax1 1.4 pmol/mg/10 min) and other a low (Km2 1.6 X 10(-6) M and Vmax2 5 pmol/mg/10 min) affinity uptake system. Desmethylimipramine at a concentration of 10(-5) M reduced the high affinity uptake of [3H]NE by 25% of the control values. Electrical stimulation of the slices increased the efflux of [3H]NE and its metabolites from tissues preloaded with [3H]NE, in a current- and frequency-dependent fashion. The release of [3H]NE and its metabolites induced by electrical stimulation (1 mA, 20 Hz, 1 ms for 2 min) was inhibited by tetrodotoxin (10(-6) M), and by a calcium-free medium containing EGTA (10(-4) M) or medium with a high magnesium-concentration (2 X 10(-2) M). These findings provide strong evidence for the neurotransmitter role of NE, in these tissues." @default.
- W2067996909 created "2016-06-24" @default.
- W2067996909 creator A5005296918 @default.
- W2067996909 creator A5033049879 @default.
- W2067996909 creator A5069189361 @default.
- W2067996909 date "1983-11-01" @default.
- W2067996909 modified "2023-10-16" @default.
- W2067996909 title "Labeled norepinephrine uptake and release in rat globus pallidus" @default.
- W2067996909 cites W1844452716 @default.
- W2067996909 cites W1907505960 @default.
- W2067996909 cites W1967192942 @default.
- W2067996909 cites W1973944624 @default.
- W2067996909 cites W1984395196 @default.
- W2067996909 cites W1989825352 @default.
- W2067996909 cites W2011737473 @default.
- W2067996909 cites W2019194654 @default.
- W2067996909 cites W2020460680 @default.
- W2067996909 cites W2024822580 @default.
- W2067996909 cites W2026341940 @default.
- W2067996909 cites W2030416184 @default.
- W2067996909 cites W2032050119 @default.
- W2067996909 cites W2051182806 @default.
- W2067996909 cites W2055383288 @default.
- W2067996909 cites W2075953804 @default.
- W2067996909 cites W2092944506 @default.
- W2067996909 cites W2113449040 @default.
- W2067996909 cites W2130762084 @default.
- W2067996909 cites W2246813284 @default.
- W2067996909 cites W2275222709 @default.
- W2067996909 cites W2282847796 @default.
- W2067996909 cites W2290063983 @default.
- W2067996909 doi "https://doi.org/10.1016/0006-8993(83)90170-1" @default.
- W2067996909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6315165" @default.
- W2067996909 hasPublicationYear "1983" @default.
- W2067996909 type Work @default.
- W2067996909 sameAs 2067996909 @default.
- W2067996909 citedByCount "9" @default.
- W2067996909 countsByYear W20679969092013 @default.
- W2067996909 crossrefType "journal-article" @default.
- W2067996909 hasAuthorship W2067996909A5005296918 @default.
- W2067996909 hasAuthorship W2067996909A5033049879 @default.
- W2067996909 hasAuthorship W2067996909A5069189361 @default.
- W2067996909 hasConcept C12554922 @default.
- W2067996909 hasConcept C126322002 @default.
- W2067996909 hasConcept C134018914 @default.
- W2067996909 hasConcept C170493617 @default.
- W2067996909 hasConcept C178790620 @default.
- W2067996909 hasConcept C185592680 @default.
- W2067996909 hasConcept C24998067 @default.
- W2067996909 hasConcept C2775894120 @default.
- W2067996909 hasConcept C2776219046 @default.
- W2067996909 hasConcept C2776741303 @default.
- W2067996909 hasConcept C2777658833 @default.
- W2067996909 hasConcept C2778187257 @default.
- W2067996909 hasConcept C2778514916 @default.
- W2067996909 hasConcept C2780278869 @default.
- W2067996909 hasConcept C513476851 @default.
- W2067996909 hasConcept C519063684 @default.
- W2067996909 hasConcept C529278444 @default.
- W2067996909 hasConcept C55493867 @default.
- W2067996909 hasConcept C71924100 @default.
- W2067996909 hasConcept C86803240 @default.
- W2067996909 hasConceptScore W2067996909C12554922 @default.
- W2067996909 hasConceptScore W2067996909C126322002 @default.
- W2067996909 hasConceptScore W2067996909C134018914 @default.
- W2067996909 hasConceptScore W2067996909C170493617 @default.
- W2067996909 hasConceptScore W2067996909C178790620 @default.
- W2067996909 hasConceptScore W2067996909C185592680 @default.
- W2067996909 hasConceptScore W2067996909C24998067 @default.
- W2067996909 hasConceptScore W2067996909C2775894120 @default.
- W2067996909 hasConceptScore W2067996909C2776219046 @default.
- W2067996909 hasConceptScore W2067996909C2776741303 @default.
- W2067996909 hasConceptScore W2067996909C2777658833 @default.
- W2067996909 hasConceptScore W2067996909C2778187257 @default.
- W2067996909 hasConceptScore W2067996909C2778514916 @default.
- W2067996909 hasConceptScore W2067996909C2780278869 @default.
- W2067996909 hasConceptScore W2067996909C513476851 @default.
- W2067996909 hasConceptScore W2067996909C519063684 @default.
- W2067996909 hasConceptScore W2067996909C529278444 @default.
- W2067996909 hasConceptScore W2067996909C55493867 @default.
- W2067996909 hasConceptScore W2067996909C71924100 @default.
- W2067996909 hasConceptScore W2067996909C86803240 @default.
- W2067996909 hasIssue "1-2" @default.
- W2067996909 hasLocation W20679969091 @default.
- W2067996909 hasLocation W20679969092 @default.
- W2067996909 hasOpenAccess W2067996909 @default.
- W2067996909 hasPrimaryLocation W20679969091 @default.
- W2067996909 hasRelatedWork W1978175539 @default.
- W2067996909 hasRelatedWork W2013272750 @default.
- W2067996909 hasRelatedWork W2035465482 @default.
- W2067996909 hasRelatedWork W2039472462 @default.
- W2067996909 hasRelatedWork W2067996909 @default.
- W2067996909 hasRelatedWork W2076012950 @default.
- W2067996909 hasRelatedWork W2076974163 @default.
- W2067996909 hasRelatedWork W2079376440 @default.
- W2067996909 hasRelatedWork W2089103608 @default.
- W2067996909 hasRelatedWork W2169102024 @default.
- W2067996909 hasVolume "279" @default.