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• W2067998912 abstract "Temperature and trace metals are common environmental stressors, and their importance is increasing due to global climate change and anthropogenic pollution. Oxidative damage and antioxidant properties have been studied in liver and gills of the European bullhead (Cottus gobio) subjected to cadmium (CdCl2 at nominal concentrations of 0.01 and 1 mg/L) for 4 days at either 15 °C or 21 °C. First, exposure to 1 mg Cd/L induced a high mortality rate (67%) in fish held at 21 °C. Regarding the antioxidant enzymes, exposure to 0.01 mg Cd/L significantly increased the activity of superoxide dismutase (SOD) and decreased the activity of glutathione reductase (GR) in liver, independently of heat stress. In gills, exposure to 21 °C resulted in a significantly increased activity of glutathione peroxidase (GPx), whereas the activity of glutathione S-transferase (GST) was significantly reduced as compared to fish exposed to 15 °C. Furthermore, regardless of Cd stress, exposure to elevated temperature resulted in a significant decrease of lipid peroxidation (LPO) level in liver and in a significant increase in the activity of chymotrypsin-like 20S proteasome in both studied tissues of C. gobio. Overall, the present results indicated that elevated temperature and cadmium exposure independently influenced the antioxidant defense system in bullhead with clear tissue-specific and stress-specific antioxidant responses. Further, elevated temperature affected the hepatic lipid peroxidation and the activity of 20S proteasome in both tissues." @default.
• W2067998912 created "2016-06-24" @default.
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• W2067998912 date "2012-03-01" @default.
• W2067998912 modified "2023-10-11" @default.
• W2067998912 title "Proteasome and antioxidant responses in Cottus gobio during a combined exposure to heat stress and cadmium" @default.
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• W2067998912 doi "https://doi.org/10.1016/j.cbpc.2011.10.003" @default.
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