FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068000325> ?p ?o ?g. }

• W2068000325 endingPage "9" @default.
• W2068000325 startingPage "3" @default.
• W2068000325 abstract "Surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) is a powerful tool for screening potential biomarkers of various pathological conditions. However, low resolution and mass accuracy of SELDI-TOF-MS remain a major obstacle for determination of biological identities of potential protein biomarkers. We report here a refined workflow that combines ZipTip desalting, acetonitrile precipitation, high-performance liquid chromatography (HPLC) separation and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) analysis for the profiling, purification and identification of the targeted serum proteins found by SELDI-TOF-MS. By using this workflow, we purified ten targeted proteins from the sera of patients with various types of advanced stage (stage III-IV) cancers. These proteins were identified as isoforms of the human serum amyloid protein A (SAA) family with or without truncations at their N-terminals. This was confirmed by Western blot analysis. Different SAA expression patterns were observed by MALDI-TOF-MS profiling. SAA has long been reported as a biomarker for various cancer types such as lung cancer, ovarian cancer, and breast cancer. However, in this study we found increased SAA expression in the sera of advanced-stage cancer patients with different cancer types. Our results suggest that maybe SAA should not be used alone as a biomarker for any specific cancer type." @default.
• W2068000325 created "2016-06-24" @default.
• W2068000325 creator A5012677271 @default.
• W2068000325 creator A5018197755 @default.
• W2068000325 creator A5027686431 @default.
• W2068000325 creator A5040134298 @default.
• W2068000325 creator A5042062615 @default.
• W2068000325 creator A5047432218 @default.
• W2068000325 creator A5048975967 @default.
• W2068000325 creator A5059257819 @default.
• W2068000325 creator A5066068619 @default.
• W2068000325 creator A5067365392 @default.
• W2068000325 creator A5078193993 @default.
• W2068000325 creator A5090659009 @default.
• W2068000325 date "2012-03-01" @default.
• W2068000325 modified "2023-10-02" @default.
• W2068000325 title "Purification, identification and profiling of serum amyloid A proteins from sera of advanced-stage cancer patients" @default.
• W2068000325 cites W1505550212 @default.
• W2068000325 cites W1651940804 @default.
• W2068000325 cites W1980971002 @default.
• W2068000325 cites W1983697384 @default.
• W2068000325 cites W1985946739 @default.
• W2068000325 cites W1988092876 @default.
• W2068000325 cites W2000011436 @default.
• W2068000325 cites W2008783277 @default.
• W2068000325 cites W2032203651 @default.
• W2068000325 cites W2034883993 @default.
• W2068000325 cites W2040729098 @default.
• W2068000325 cites W2057977080 @default.
• W2068000325 cites W2058670939 @default.
• W2068000325 cites W2059871118 @default.
• W2068000325 cites W2062212784 @default.
• W2068000325 cites W2071359701 @default.
• W2068000325 cites W2076887271 @default.
• W2068000325 cites W2078355311 @default.
• W2068000325 cites W2078859186 @default.
• W2068000325 cites W2080705803 @default.
• W2068000325 cites W2082620667 @default.
• W2068000325 cites W2087839294 @default.
• W2068000325 cites W2106261345 @default.
• W2068000325 cites W2107177647 @default.
• W2068000325 cites W2112531505 @default.
• W2068000325 cites W2130296644 @default.
• W2068000325 cites W2134389439 @default.
• W2068000325 cites W2143233121 @default.
• W2068000325 cites W2146321139 @default.
• W2068000325 cites W2150691772 @default.
• W2068000325 cites W2151655754 @default.
• W2068000325 cites W2155478415 @default.
• W2068000325 cites W2158990205 @default.
• W2068000325 cites W2161695764 @default.
• W2068000325 cites W2162386068 @default.
• W2068000325 cites W2167328524 @default.
• W2068000325 cites W2172116519 @default.
• W2068000325 cites W2172300860 @default.
• W2068000325 doi "https://doi.org/10.1016/j.jchromb.2012.01.002" @default.
• W2068000325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7105184" @default.
• W2068000325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22341353" @default.
• W2068000325 hasPublicationYear "2012" @default.
• W2068000325 type Work @default.
• W2068000325 sameAs 2068000325 @default.
• W2068000325 citedByCount "15" @default.
• W2068000325 countsByYear W20680003252012 @default.
• W2068000325 countsByYear W20680003252013 @default.
• W2068000325 countsByYear W20680003252014 @default.
• W2068000325 countsByYear W20680003252015 @default.
• W2068000325 countsByYear W20680003252017 @default.
• W2068000325 countsByYear W20680003252018 @default.
• W2068000325 countsByYear W20680003252019 @default.
• W2068000325 countsByYear W20680003252020 @default.
• W2068000325 countsByYear W20680003252021 @default.
• W2068000325 countsByYear W20680003252022 @default.
• W2068000325 crossrefType "journal-article" @default.
• W2068000325 hasAuthorship W2068000325A5012677271 @default.
• W2068000325 hasAuthorship W2068000325A5018197755 @default.
• W2068000325 hasAuthorship W2068000325A5027686431 @default.
• W2068000325 hasAuthorship W2068000325A5040134298 @default.
• W2068000325 hasAuthorship W2068000325A5042062615 @default.
• W2068000325 hasAuthorship W2068000325A5047432218 @default.
• W2068000325 hasAuthorship W2068000325A5048975967 @default.
• W2068000325 hasAuthorship W2068000325A5059257819 @default.
• W2068000325 hasAuthorship W2068000325A5066068619 @default.
• W2068000325 hasAuthorship W2068000325A5067365392 @default.
• W2068000325 hasAuthorship W2068000325A5078193993 @default.
• W2068000325 hasAuthorship W2068000325A5090659009 @default.
• W2068000325 hasBestOaLocation W20680003251 @default.
• W2068000325 hasConcept C104317684 @default.
• W2068000325 hasConcept C121608353 @default.
• W2068000325 hasConcept C124535831 @default.
• W2068000325 hasConcept C126322002 @default.
• W2068000325 hasConcept C139883154 @default.
• W2068000325 hasConcept C145148216 @default.
• W2068000325 hasConcept C162356407 @default.
• W2068000325 hasConcept C16291436 @default.
• W2068000325 hasConcept C178790620 @default.
• W2068000325 hasConcept C185592680 @default.
• W2068000325 hasConcept C198291218 @default.
• W2068000325 hasConcept C202157981 @default.

• next