Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068001868> ?p ?o ?g. }
- W2068001868 endingPage "1638" @default.
- W2068001868 startingPage "1630" @default.
- W2068001868 abstract "Abstract: The in vitro degradation of microtubule-associated protein 2 (MAP-2) and spectrin by the calcium-dependent neutral protease calpain was studied. Five major results are reported. First, MAP-2 isolated from twice-cycled microtubules (2XMT MAP-2) was extremely sensitive to calpain-induced hydrolysis. Even at an enzyme-to-substrate ratio (wt/wt) of 1:200, 2XMT MAP-2 was significantly degraded by calpain. Second, MAP-2 purified from the total brain heat-stable fraction (total MAP-2) was significantly more resistant to calpain-induced hydrolysis compared with 2XMT MAP-2. Third, MAP-2a and MAP-2b were proteolyzed similarly by calpain, although some relative resistance of MAP-2b was observed. Fourth, the presence of calmodulin significantly increased the extent of calpain-induced hydrolysis of the α-subunit of spectrin. Fifth, the two neuronal isoforms of brain spectrin (240/235 and 240/235E, referred to as α/βN and α/βE, respectively) showed different sensitivities to calpain. αN-spectrin was significantly more sensitive to calpain-induced degradation compared to αE-spectrin. Among other things, these results suggest a role for the calpain-induced degradation of MAP-2, as well as spectrin, in such physiological processes as alterations in synaptic efficacy, dendritic remodeling, and in pathological processes associated with neurodegeneration." @default.
- W2068001868 created "2016-06-24" @default.
- W2068001868 creator A5025207687 @default.
- W2068001868 creator A5037199856 @default.
- W2068001868 creator A5044626267 @default.
- W2068001868 date "1991-05-01" @default.
- W2068001868 modified "2023-09-27" @default.
- W2068001868 title "Degradation of Microtubule-Associated Protein 2 and Brain Spectrin by Calpain: A Comparative Study" @default.
- W2068001868 cites W124166619 @default.
- W2068001868 cites W1509584111 @default.
- W2068001868 cites W1511060530 @default.
- W2068001868 cites W1546705165 @default.
- W2068001868 cites W1552233393 @default.
- W2068001868 cites W1568636663 @default.
- W2068001868 cites W1570260604 @default.
- W2068001868 cites W1580947142 @default.
- W2068001868 cites W1583781439 @default.
- W2068001868 cites W1587065131 @default.
- W2068001868 cites W1590154399 @default.
- W2068001868 cites W1623233150 @default.
- W2068001868 cites W1951784167 @default.
- W2068001868 cites W1978898121 @default.
- W2068001868 cites W1979406476 @default.
- W2068001868 cites W1986369075 @default.
- W2068001868 cites W1989178946 @default.
- W2068001868 cites W1992526188 @default.
- W2068001868 cites W2003293852 @default.
- W2068001868 cites W2005132906 @default.
- W2068001868 cites W2012116143 @default.
- W2068001868 cites W2026101249 @default.
- W2068001868 cites W2029394130 @default.
- W2068001868 cites W2030804101 @default.
- W2068001868 cites W2036464759 @default.
- W2068001868 cites W2049586804 @default.
- W2068001868 cites W2052881212 @default.
- W2068001868 cites W2053032188 @default.
- W2068001868 cites W2055277461 @default.
- W2068001868 cites W2063272135 @default.
- W2068001868 cites W2070772311 @default.
- W2068001868 cites W2078382210 @default.
- W2068001868 cites W2080399942 @default.
- W2068001868 cites W2082806723 @default.
- W2068001868 cites W2084192074 @default.
- W2068001868 cites W2093480892 @default.
- W2068001868 cites W2093947387 @default.
- W2068001868 cites W2095180840 @default.
- W2068001868 cites W2101108802 @default.
- W2068001868 cites W2109423788 @default.
- W2068001868 cites W2119139468 @default.
- W2068001868 cites W2127478703 @default.
- W2068001868 cites W2137809055 @default.
- W2068001868 cites W2159872854 @default.
- W2068001868 cites W2160720263 @default.
- W2068001868 cites W2166585705 @default.
- W2068001868 cites W2206785872 @default.
- W2068001868 cites W2208731726 @default.
- W2068001868 cites W2235497272 @default.
- W2068001868 cites W2418520130 @default.
- W2068001868 cites W4229666614 @default.
- W2068001868 doi "https://doi.org/10.1111/j.1471-4159.1991.tb02061.x" @default.
- W2068001868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2013758" @default.
- W2068001868 hasPublicationYear "1991" @default.
- W2068001868 type Work @default.
- W2068001868 sameAs 2068001868 @default.
- W2068001868 citedByCount "177" @default.
- W2068001868 countsByYear W20680018682012 @default.
- W2068001868 countsByYear W20680018682013 @default.
- W2068001868 countsByYear W20680018682014 @default.
- W2068001868 countsByYear W20680018682015 @default.
- W2068001868 countsByYear W20680018682017 @default.
- W2068001868 countsByYear W20680018682019 @default.
- W2068001868 countsByYear W20680018682020 @default.
- W2068001868 countsByYear W20680018682021 @default.
- W2068001868 countsByYear W20680018682022 @default.
- W2068001868 countsByYear W20680018682023 @default.
- W2068001868 crossrefType "journal-article" @default.
- W2068001868 hasAuthorship W2068001868A5025207687 @default.
- W2068001868 hasAuthorship W2068001868A5037199856 @default.
- W2068001868 hasAuthorship W2068001868A5044626267 @default.
- W2068001868 hasConcept C126322002 @default.
- W2068001868 hasConcept C142669718 @default.
- W2068001868 hasConcept C1491633281 @default.
- W2068001868 hasConcept C153911025 @default.
- W2068001868 hasConcept C181199279 @default.
- W2068001868 hasConcept C185592680 @default.
- W2068001868 hasConcept C20418707 @default.
- W2068001868 hasConcept C2776714187 @default.
- W2068001868 hasConcept C2776925932 @default.
- W2068001868 hasConcept C2779134260 @default.
- W2068001868 hasConcept C2781307694 @default.
- W2068001868 hasConcept C50244902 @default.
- W2068001868 hasConcept C55493867 @default.
- W2068001868 hasConcept C56928146 @default.
- W2068001868 hasConcept C61081601 @default.
- W2068001868 hasConcept C71924100 @default.
- W2068001868 hasConcept C86803240 @default.
- W2068001868 hasConcept C95444343 @default.
- W2068001868 hasConceptScore W2068001868C126322002 @default.