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• W2068003655 abstract "A normal-phase high-performance liquid chromatographic method was developed to determine therapeutic concentrations of trimethoprim, sulphamethoxazole, and its N4-acetyl derivative in biological fluids. The compounds are extracted at pH 6.2 using ethyl acetate—chloroform in a single extraction. The detection limit is 15 ng/ml for trimethoprim, 20 ng/ml for sulphamethoxazole, and 10 ng/ml for its N4-acetyl metabolite. The method is rapid, sensitive, precise, and well suited to clinical pharmacokinetic investigations." @default.
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• W2068003655 date "1983-01-01" @default.
• W2068003655 modified "2023-10-16" @default.
• W2068003655 title "Determination of trimethoprim, sulphamethoxazole and its N4-acetyl metabolite in biological fluids by high-performance liquid chromatography" @default.
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• W2068003655 doi "https://doi.org/10.1016/s0378-4347(00)84422-9" @default.
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