FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068005122> ?p ?o ?g. }

• W2068005122 endingPage "179" @default.
• W2068005122 startingPage "168" @default.
• W2068005122 abstract "Abstract This paper reviews the development in the 1950s of methods to determine the redox states of the free [NAD + ]/[NADH] in cytoplasm of yeast by Helmut Holzer and Feodore Lynen and in rat liver by Theodore Bucher and Martin Klingenberg. This work was extended in the 1960s in the laboratory of Hans Krebs, where the use of basic thermodynamic and kinetic principles allowed the extension of this approach to the determination of the free mitochondrial [NAD + ]/NADH] in mitochondria and the redox state of the free NADP system in cytoplasm and mitochondria. This work also outlined the linkage between the redox states in the various couples to the phosphorylation state or the free [ATP]/[ADP][P i ] ratio, the central energy parameter of living cells. This work has since been extended to include other energy‐linked systems including the gradients of inorganic ions between extra and intracellular phases of the cell and the redox state of the co‐enzyme Q couple of mitochondria. This system of linked near‐equilibrium redox and phosphorylation potentials constitutes a framework of primitive metabolic control that is altered in a number of disease phenotypes. The alteration of such disease phenotypes by substrate availability is discussed, as well as the importance of a thorough grounding in basic kinetics and thermodynamics in designing new therapies to normalize the metabolic abnormalities that are the proximate cause of many common and some rare diseases states." @default.
• W2068005122 created "2016-06-24" @default.
• W2068005122 creator A5004652247 @default.
• W2068005122 date "2006-05-01" @default.
• W2068005122 modified "2023-10-16" @default.
• W2068005122 title "The determination of the redox states and phosphorylation potential in living tissues and their relationship to metabolic control of disease phenotypes" @default.
• W2068005122 cites W1480936801 @default.
• W2068005122 cites W1485030470 @default.
• W2068005122 cites W1486293218 @default.
• W2068005122 cites W1488748351 @default.
• W2068005122 cites W1512854463 @default.
• W2068005122 cites W1535979687 @default.
• W2068005122 cites W1537051433 @default.
• W2068005122 cites W1544740422 @default.
• W2068005122 cites W1546087498 @default.
• W2068005122 cites W1573693094 @default.
• W2068005122 cites W1581338941 @default.
• W2068005122 cites W1582646265 @default.
• W2068005122 cites W1586233686 @default.
• W2068005122 cites W15903428 @default.
• W2068005122 cites W1665675901 @default.
• W2068005122 cites W1738677317 @default.
• W2068005122 cites W1759750343 @default.
• W2068005122 cites W1801184284 @default.
• W2068005122 cites W1906761164 @default.
• W2068005122 cites W1932376175 @default.
• W2068005122 cites W1971503932 @default.
• W2068005122 cites W2004268886 @default.
• W2068005122 cites W2020260197 @default.
• W2068005122 cites W2022704484 @default.
• W2068005122 cites W202393247 @default.
• W2068005122 cites W2035295072 @default.
• W2068005122 cites W2051764674 @default.
• W2068005122 cites W2052575378 @default.
• W2068005122 cites W2063041018 @default.
• W2068005122 cites W2069752613 @default.
• W2068005122 cites W2083741341 @default.
• W2068005122 cites W2090600090 @default.
• W2068005122 cites W2094655709 @default.
• W2068005122 cites W2101042964 @default.
• W2068005122 cites W2104938317 @default.
• W2068005122 cites W2116035317 @default.
• W2068005122 cites W2132826785 @default.
• W2068005122 cites W2133870531 @default.
• W2068005122 cites W2136829516 @default.
• W2068005122 cites W2158025896 @default.
• W2068005122 cites W2321274769 @default.
• W2068005122 cites W2407901949 @default.
• W2068005122 cites W2412467438 @default.
• W2068005122 cites W2413138043 @default.
• W2068005122 cites W2432195370 @default.
• W2068005122 cites W2801089658 @default.
• W2068005122 cites W4246800229 @default.
• W2068005122 cites W44177347 @default.
• W2068005122 doi "https://doi.org/10.1002/bmb.2006.49403403168" @default.
• W2068005122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21638666" @default.
• W2068005122 hasPublicationYear "2006" @default.
• W2068005122 type Work @default.
• W2068005122 sameAs 2068005122 @default.
• W2068005122 citedByCount "34" @default.
• W2068005122 countsByYear W20680051222012 @default.
• W2068005122 countsByYear W20680051222013 @default.
• W2068005122 countsByYear W20680051222014 @default.
• W2068005122 countsByYear W20680051222015 @default.
• W2068005122 countsByYear W20680051222016 @default.
• W2068005122 countsByYear W20680051222017 @default.
• W2068005122 countsByYear W20680051222018 @default.
• W2068005122 countsByYear W20680051222019 @default.
• W2068005122 countsByYear W20680051222020 @default.
• W2068005122 countsByYear W20680051222021 @default.
• W2068005122 countsByYear W20680051222023 @default.
• W2068005122 crossrefType "journal-article" @default.
• W2068005122 hasAuthorship W2068005122A5004652247 @default.
• W2068005122 hasBestOaLocation W20680051221 @default.
• W2068005122 hasConcept C100206155 @default.
• W2068005122 hasConcept C12554922 @default.
• W2068005122 hasConcept C178790620 @default.
• W2068005122 hasConcept C181199279 @default.
• W2068005122 hasConcept C185592680 @default.
• W2068005122 hasConcept C190062978 @default.
• W2068005122 hasConcept C192989942 @default.
• W2068005122 hasConcept C28859421 @default.
• W2068005122 hasConcept C55493867 @default.
• W2068005122 hasConcept C55904794 @default.
• W2068005122 hasConcept C57600042 @default.
• W2068005122 hasConcept C62231903 @default.
• W2068005122 hasConcept C75520062 @default.
• W2068005122 hasConcept C79879829 @default.
• W2068005122 hasConcept C86803240 @default.
• W2068005122 hasConcept C95444343 @default.
• W2068005122 hasConceptScore W2068005122C100206155 @default.
• W2068005122 hasConceptScore W2068005122C12554922 @default.
• W2068005122 hasConceptScore W2068005122C178790620 @default.
• W2068005122 hasConceptScore W2068005122C181199279 @default.
• W2068005122 hasConceptScore W2068005122C185592680 @default.
• W2068005122 hasConceptScore W2068005122C190062978 @default.
• W2068005122 hasConceptScore W2068005122C192989942 @default.
• W2068005122 hasConceptScore W2068005122C28859421 @default.

• next