FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068006123> ?p ?o ?g. }

• W2068006123 endingPage "3112" @default.
• W2068006123 startingPage "3105" @default.
• W2068006123 abstract "The interactions of three therapeutic agents, viz. the antipsychotics HPD and CPZ, and the antineoplastic anthracycline DOX, with oxidatively modified phospholipids were studied by monitoring the quenching of fluorescence of an incorporated pyrene-labeled lipid derivative. All three drugs bound avidly to the two oxidized PCs bearing either an aldehyde or carboxylic function at the end of the sn-2 nonanoyl chain, with the highest affinity measured between CPZ and the latter oxidized lipid. Subsequent dissociation of the above drugs from the oxidized lipids by DNA, acidic phospholipids, and NaCl revealed the binding of these drugs with the aldehyde lipid to be driven by hydrophobicity similarly to their binding to lysophosphatidylcholine, whereas a significant contribution of electrostatics was evident for the lipid with the carboxylic moiety. These results connect to previous experimental data, demonstrating the induction by these drugs of oxidative stress and binding to membrane phospholipids. These issues are elaborated with reference to their clinical use and side effects." @default.
• W2068006123 created "2016-06-24" @default.
• W2068006123 creator A5056697656 @default.
• W2068006123 creator A5078596818 @default.
• W2068006123 creator A5091809643 @default.
• W2068006123 date "2007-11-01" @default.
• W2068006123 modified "2023-10-18" @default.
• W2068006123 title "Oxidized Phospholipids as Potential Novel Drug Targets" @default.
• W2068006123 cites W1488499007 @default.
• W2068006123 cites W1599570426 @default.
• W2068006123 cites W1605916516 @default.
• W2068006123 cites W1734082729 @default.
• W2068006123 cites W1920198420 @default.
• W2068006123 cites W1970490535 @default.
• W2068006123 cites W1972350913 @default.
• W2068006123 cites W1976428161 @default.
• W2068006123 cites W1980237253 @default.
• W2068006123 cites W1987827192 @default.
• W2068006123 cites W1996015317 @default.
• W2068006123 cites W2002088627 @default.
• W2068006123 cites W2003614392 @default.
• W2068006123 cites W2009186000 @default.
• W2068006123 cites W2010183849 @default.
• W2068006123 cites W2016293448 @default.
• W2068006123 cites W2016486229 @default.
• W2068006123 cites W2020158264 @default.
• W2068006123 cites W2024285057 @default.
• W2068006123 cites W2024314179 @default.
• W2068006123 cites W2033692899 @default.
• W2068006123 cites W2034697895 @default.
• W2068006123 cites W2035215935 @default.
• W2068006123 cites W2056598627 @default.
• W2068006123 cites W2076305935 @default.
• W2068006123 cites W2080742616 @default.
• W2068006123 cites W2086546422 @default.
• W2068006123 cites W2088049429 @default.
• W2068006123 cites W2092507495 @default.
• W2068006123 cites W2106809354 @default.
• W2068006123 cites W2123297201 @default.
• W2068006123 cites W2124634545 @default.
• W2068006123 cites W2159364758 @default.
• W2068006123 cites W2162417581 @default.
• W2068006123 cites W2302907248 @default.
• W2068006123 cites W2411195784 @default.
• W2068006123 cites W1896435317 @default.
• W2068006123 doi "https://doi.org/10.1529/biophysj.107.103887" @default.
• W2068006123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2025674" @default.
• W2068006123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17604316" @default.
• W2068006123 hasPublicationYear "2007" @default.
• W2068006123 type Work @default.
• W2068006123 sameAs 2068006123 @default.
• W2068006123 citedByCount "31" @default.
• W2068006123 countsByYear W20680061232012 @default.
• W2068006123 countsByYear W20680061232013 @default.
• W2068006123 countsByYear W20680061232015 @default.
• W2068006123 countsByYear W20680061232016 @default.
• W2068006123 countsByYear W20680061232017 @default.
• W2068006123 countsByYear W20680061232019 @default.
• W2068006123 countsByYear W20680061232020 @default.
• W2068006123 countsByYear W20680061232022 @default.
• W2068006123 countsByYear W20680061232023 @default.
• W2068006123 crossrefType "journal-article" @default.
• W2068006123 hasAuthorship W2068006123A5056697656 @default.
• W2068006123 hasAuthorship W2068006123A5078596818 @default.
• W2068006123 hasAuthorship W2068006123A5091809643 @default.
• W2068006123 hasBestOaLocation W20680061231 @default.
• W2068006123 hasConcept C102931765 @default.
• W2068006123 hasConcept C161790260 @default.
• W2068006123 hasConcept C178790620 @default.
• W2068006123 hasConcept C185154212 @default.
• W2068006123 hasConcept C185592680 @default.
• W2068006123 hasConcept C21951064 @default.
• W2068006123 hasConcept C2776151105 @default.
• W2068006123 hasConcept C2776330855 @default.
• W2068006123 hasConcept C2776568683 @default.
• W2068006123 hasConcept C2778596009 @default.
• W2068006123 hasConcept C2778918659 @default.
• W2068006123 hasConcept C2779825165 @default.
• W2068006123 hasConcept C2780035454 @default.
• W2068006123 hasConcept C41625074 @default.
• W2068006123 hasConcept C55493867 @default.
• W2068006123 hasConcept C71240020 @default.
• W2068006123 hasConcept C71924100 @default.
• W2068006123 hasConcept C98274493 @default.
• W2068006123 hasConceptScore W2068006123C102931765 @default.
• W2068006123 hasConceptScore W2068006123C161790260 @default.
• W2068006123 hasConceptScore W2068006123C178790620 @default.
• W2068006123 hasConceptScore W2068006123C185154212 @default.
• W2068006123 hasConceptScore W2068006123C185592680 @default.
• W2068006123 hasConceptScore W2068006123C21951064 @default.
• W2068006123 hasConceptScore W2068006123C2776151105 @default.
• W2068006123 hasConceptScore W2068006123C2776330855 @default.
• W2068006123 hasConceptScore W2068006123C2776568683 @default.
• W2068006123 hasConceptScore W2068006123C2778596009 @default.
• W2068006123 hasConceptScore W2068006123C2778918659 @default.
• W2068006123 hasConceptScore W2068006123C2779825165 @default.
• W2068006123 hasConceptScore W2068006123C2780035454 @default.
• W2068006123 hasConceptScore W2068006123C41625074 @default.

• next