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- W2068009069 abstract "Wnt signaling cascades play a crucial role in the maintenance of stem cell niches in many tissues as well as in embryonic patterning and cell-fate determination. Wnt signaling pathways have been well studied; however, the precise binding mechanism of Wnt protein to its receptor has not yet been clarified. Here we show the design and synthesis of seven novel peptide candidates for a receptor-binding site of human Wnt-1 based on its hydrophilicity and β-turn profiles. Among these Wnt-derived peptides, only WP7, which corresponds to residues 301–320 of human Wnt-1, bound to the soluble receptor for Wnt-1, mouse Frizzled-1/Fc chimera, promoted PC12 cell adherence, increased level of cytosolic β-catenin in PC12 cells, and induced adhesion and neuronal differentiation of hippocampal neural precursor cells. These results suggest that residues 301–320 of human Wnt-1 is one of the receptor-binding sites and that WP7 may activate the canonical Wnt pathway. When combined with an appropriate matrix, the action of this Wnt-derived peptide, WP7, can be limited to within a location, and therefore could be useful in the regeneration of many tissues, without fear of tumor generation." @default.
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- W2068009069 date "2008-09-01" @default.
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- W2068009069 title "A synthetic peptide corresponding to residues 301–320 of human Wnt-1 promotes PC12 cell adhesion and hippocampal neural stem cell differentiation" @default.
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- W2068009069 doi "https://doi.org/10.1016/j.peptides.2008.05.013" @default.
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