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• W2068017968 abstract "Axons and dendrites of developing neurons establish distributed innervation patterns enabling precise discrimination in sensory systems. We describe the role of the extracellular matrix molecule, laminin β2, interacting with the Ca V 2.2 calcium channel in establishing appropriate sensory innervation. In vivo , Ca V 2.2 is expressed on the growth cones of Xenopus laevis sensory neurites and laminin β2 is expressed in the skin. Culturing neurons on a laminin β2 substrate inhibits neurite outgrowth in a specific and calcium-dependent manner. Blocking signaling between laminin β2 and Ca V 2.2 leads to increased numbers of sensory terminals in vivo . These findings suggest that interactions between extracellular matrix molecules and calcium channels regulate connectivity in the developing nervous system." @default.
• W2068017968 created "2016-06-24" @default.
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• W2068017968 date "2008-03-05" @default.
• W2068017968 modified "2023-09-25" @default.
• W2068017968 title "Neurite Outgrowth and<i>In Vivo</i>Sensory Innervation Mediated by a Ca_V2.2–Laminin β2 Stop Signal" @default.
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• W2068017968 doi "https://doi.org/10.1523/jneurosci.3828-07.2008" @default.
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