FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068018184> ?p ?o ?g. }

• W2068018184 endingPage "e102" @default.
• W2068018184 startingPage "e102" @default.
• W2068018184 abstract "Progesterone and estrogen are critical regulators of uterine receptivity. To facilitate uterine remodeling for embryo attachment, estrogen activity in the uterine epithelia is attenuated by progesterone; however, the molecular mechanism by which this occurs is poorly defined. COUP-TFII (chicken ovalbumin upstream promoter transcription factor II; also known as NR2F2), a member of the nuclear receptor superfamily, is highly expressed in the uterine stroma and its expression is regulated by the progesterone-Indian hedgehog-Patched signaling axis that emanates from the epithelium. To further assess COUP-TFII uterine function, a conditional COUP-TFII knockout mouse was generated. This mutant mouse is infertile due to implantation failure, in which both embryo attachment and uterine decidualization are impaired. Using this animal model, we have identified a novel genetic pathway in which BMP2 lies downstream of COUP-TFII. Epithelial progesterone-induced Indian hedgehog regulates stromal COUP-TFII, which in turn controls BMP2 to allow decidualization to manifest in vivo. Interestingly, enhanced epithelial estrogen activity, which impedes maturation of the receptive uterus, was clearly observed in the absence of stromal-derived COUP-TFII. This finding is consistent with the notion that progesterone exerts its control of implantation through uterine epithelial-stromal cross-talk and reveals that stromal-derived COUP-TFII is an essential mediator of this complex cross-communication pathway. This finding also provides a new signaling paradigm for steroid hormone regulation in female reproductive biology, with attendant implications for furthering our understanding of the molecular mechanisms that underlie dysregulation of hormonal signaling in such human reproductive disorders as endometriosis and endometrial cancer." @default.
• W2068018184 created "2016-06-24" @default.
• W2068018184 creator A5010280433 @default.
• W2068018184 creator A5038464425 @default.
• W2068018184 creator A5060789409 @default.
• W2068018184 creator A5064070422 @default.
• W2068018184 creator A5065573214 @default.
• W2068018184 creator A5068974547 @default.
• W2068018184 creator A5069048623 @default.
• W2068018184 creator A5082214330 @default.
• W2068018184 creator A5087051994 @default.
• W2068018184 date "2007-06-22" @default.
• W2068018184 modified "2023-10-16" @default.
• W2068018184 title "COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER Activity" @default.
• W2068018184 cites W1516590629 @default.
• W2068018184 cites W1698663755 @default.
• W2068018184 cites W1915582829 @default.
• W2068018184 cites W1921540406 @default.
• W2068018184 cites W1964841323 @default.
• W2068018184 cites W1972018407 @default.
• W2068018184 cites W1972767512 @default.
• W2068018184 cites W1976999163 @default.
• W2068018184 cites W1981075723 @default.
• W2068018184 cites W1986872599 @default.
• W2068018184 cites W1990498979 @default.
• W2068018184 cites W1994935017 @default.
• W2068018184 cites W1998417786 @default.
• W2068018184 cites W2007039255 @default.
• W2068018184 cites W2011545537 @default.
• W2068018184 cites W2011590093 @default.
• W2068018184 cites W2012155675 @default.
• W2068018184 cites W2012532001 @default.
• W2068018184 cites W2023586275 @default.
• W2068018184 cites W2023618350 @default.
• W2068018184 cites W2024949021 @default.
• W2068018184 cites W2027395750 @default.
• W2068018184 cites W2031512686 @default.
• W2068018184 cites W2049184335 @default.
• W2068018184 cites W2049516851 @default.
• W2068018184 cites W2052777384 @default.
• W2068018184 cites W2062558128 @default.
• W2068018184 cites W2070082499 @default.
• W2068018184 cites W2070750387 @default.
• W2068018184 cites W2070944119 @default.
• W2068018184 cites W2072376737 @default.
• W2068018184 cites W2074168165 @default.
• W2068018184 cites W2076649161 @default.
• W2068018184 cites W2082559087 @default.
• W2068018184 cites W2086198420 @default.
• W2068018184 cites W2097778650 @default.
• W2068018184 cites W2101797955 @default.
• W2068018184 cites W2102117398 @default.
• W2068018184 cites W2103567361 @default.
• W2068018184 cites W2108376889 @default.
• W2068018184 cites W2109254966 @default.
• W2068018184 cites W2111071490 @default.
• W2068018184 cites W2113668968 @default.
• W2068018184 cites W2123100180 @default.
• W2068018184 cites W2130463115 @default.
• W2068018184 cites W2131074211 @default.
• W2068018184 cites W2138605813 @default.
• W2068018184 cites W2139259772 @default.
• W2068018184 cites W2146815069 @default.
• W2068018184 cites W2147185796 @default.
• W2068018184 cites W2148734624 @default.
• W2068018184 cites W2149220734 @default.
• W2068018184 cites W2161121464 @default.
• W2068018184 cites W2163103493 @default.
• W2068018184 cites W2168240431 @default.
• W2068018184 cites W2188419301 @default.
• W2068018184 cites W4211232189 @default.
• W2068018184 cites W4234813513 @default.
• W2068018184 cites W4250362717 @default.
• W2068018184 doi "https://doi.org/10.1371/journal.pgen.0030102" @default.
• W2068018184 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1892047" @default.
• W2068018184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17590085" @default.
• W2068018184 hasPublicationYear "2007" @default.
• W2068018184 type Work @default.
• W2068018184 sameAs 2068018184 @default.
• W2068018184 citedByCount "165" @default.
• W2068018184 countsByYear W20680181842012 @default.
• W2068018184 countsByYear W20680181842013 @default.
• W2068018184 countsByYear W20680181842014 @default.
• W2068018184 countsByYear W20680181842015 @default.
• W2068018184 countsByYear W20680181842016 @default.
• W2068018184 countsByYear W20680181842017 @default.
• W2068018184 countsByYear W20680181842018 @default.
• W2068018184 countsByYear W20680181842019 @default.
• W2068018184 countsByYear W20680181842020 @default.
• W2068018184 countsByYear W20680181842021 @default.
• W2068018184 countsByYear W20680181842022 @default.
• W2068018184 countsByYear W20680181842023 @default.
• W2068018184 crossrefType "journal-article" @default.
• W2068018184 hasAuthorship W2068018184A5010280433 @default.
• W2068018184 hasAuthorship W2068018184A5038464425 @default.
• W2068018184 hasAuthorship W2068018184A5060789409 @default.
• W2068018184 hasAuthorship W2068018184A5064070422 @default.
• W2068018184 hasAuthorship W2068018184A5065573214 @default.

• next