FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068019148> ?p ?o ?g. }

• W2068019148 endingPage "335" @default.
• W2068019148 startingPage "331" @default.
• W2068019148 abstract "The currently available drugs for treatment of Alzheimer's disease are symptomatic and only temporarily slow down the natural history of the disease process. Recently, its has been proposed that the combination of memantine with vitamin D, a neurosteroid hormone, may prevent amyloid-beta and glutamate neurotoxicity. Here, our purpose was to examine the potential protective effects of memantine and vitamin D against amyloid-beta peptide and glutamate toxicity in cortical neuronal cultures. We provide the first evidence that cortical axons degenerate less after exposure to amyloid-beta peptide or glutamate in microfluidic neuronal cultures enriched with memantine plus vitamin D compared to control medium and cultures enriched with only memantine or only vitamin D. The reported synergistic neuroprotective effect of memantine plus vitamin D -the combination originating an effect stronger than the sum- corroborate previous clinical finding that Alzheimer's disease patients using this drug combination have improved cognition. This finding reinforces the pharmacological potential of a new drug combining memantine plus vitamin D for the treatment or the prevention of Alzheimer's disease." @default.
• W2068019148 created "2016-06-24" @default.
• W2068019148 creator A5006105927 @default.
• W2068019148 creator A5010262899 @default.
• W2068019148 creator A5011579867 @default.
• W2068019148 creator A5044984923 @default.
• W2068019148 creator A5079647441 @default.
• W2068019148 date "2014-02-01" @default.
• W2068019148 modified "2023-09-27" @default.
• W2068019148 title "Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate" @default.
• W2068019148 cites W1487935461 @default.
• W2068019148 cites W1557365633 @default.
• W2068019148 cites W1965514557 @default.
• W2068019148 cites W1974362648 @default.
• W2068019148 cites W1977785286 @default.
• W2068019148 cites W1980432511 @default.
• W2068019148 cites W1990368582 @default.
• W2068019148 cites W1993943874 @default.
• W2068019148 cites W2007627173 @default.
• W2068019148 cites W2013431267 @default.
• W2068019148 cites W2033283296 @default.
• W2068019148 cites W2036564583 @default.
• W2068019148 cites W2037096800 @default.
• W2068019148 cites W2047242898 @default.
• W2068019148 cites W2054877919 @default.
• W2068019148 cites W2057578283 @default.
• W2068019148 cites W2057852102 @default.
• W2068019148 cites W2094766497 @default.
• W2068019148 cites W2099665543 @default.
• W2068019148 cites W2100728233 @default.
• W2068019148 cites W2111598959 @default.
• W2068019148 cites W2112837687 @default.
• W2068019148 cites W2114163624 @default.
• W2068019148 cites W2126583244 @default.
• W2068019148 cites W2138328097 @default.
• W2068019148 cites W2147654688 @default.
• W2068019148 cites W2153784703 @default.
• W2068019148 cites W4319308399 @default.
• W2068019148 doi "https://doi.org/10.1016/j.neurobiolaging.2013.07.029" @default.
• W2068019148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24011542" @default.
• W2068019148 hasPublicationYear "2014" @default.
• W2068019148 type Work @default.
• W2068019148 sameAs 2068019148 @default.
• W2068019148 citedByCount "52" @default.
• W2068019148 countsByYear W20680191482013 @default.
• W2068019148 countsByYear W20680191482014 @default.
• W2068019148 countsByYear W20680191482015 @default.
• W2068019148 countsByYear W20680191482016 @default.
• W2068019148 countsByYear W20680191482017 @default.
• W2068019148 countsByYear W20680191482018 @default.
• W2068019148 countsByYear W20680191482019 @default.
• W2068019148 countsByYear W20680191482020 @default.
• W2068019148 countsByYear W20680191482021 @default.
• W2068019148 countsByYear W20680191482022 @default.
• W2068019148 countsByYear W20680191482023 @default.
• W2068019148 crossrefType "journal-article" @default.
• W2068019148 hasAuthorship W2068019148A5006105927 @default.
• W2068019148 hasAuthorship W2068019148A5010262899 @default.
• W2068019148 hasAuthorship W2068019148A5011579867 @default.
• W2068019148 hasAuthorship W2068019148A5044984923 @default.
• W2068019148 hasAuthorship W2068019148A5079647441 @default.
• W2068019148 hasConcept C124490489 @default.
• W2068019148 hasConcept C126322002 @default.
• W2068019148 hasConcept C170493617 @default.
• W2068019148 hasConcept C185592680 @default.
• W2068019148 hasConcept C25498285 @default.
• W2068019148 hasConcept C2776156579 @default.
• W2068019148 hasConcept C2779134260 @default.
• W2068019148 hasConcept C2779483572 @default.
• W2068019148 hasConcept C2779484449 @default.
• W2068019148 hasConcept C2779491297 @default.
• W2068019148 hasConcept C29730261 @default.
• W2068019148 hasConcept C61174792 @default.
• W2068019148 hasConcept C71924100 @default.
• W2068019148 hasConcept C98274493 @default.
• W2068019148 hasConceptScore W2068019148C124490489 @default.
• W2068019148 hasConceptScore W2068019148C126322002 @default.
• W2068019148 hasConceptScore W2068019148C170493617 @default.
• W2068019148 hasConceptScore W2068019148C185592680 @default.
• W2068019148 hasConceptScore W2068019148C25498285 @default.
• W2068019148 hasConceptScore W2068019148C2776156579 @default.
• W2068019148 hasConceptScore W2068019148C2779134260 @default.
• W2068019148 hasConceptScore W2068019148C2779483572 @default.
• W2068019148 hasConceptScore W2068019148C2779484449 @default.
• W2068019148 hasConceptScore W2068019148C2779491297 @default.
• W2068019148 hasConceptScore W2068019148C29730261 @default.
• W2068019148 hasConceptScore W2068019148C61174792 @default.
• W2068019148 hasConceptScore W2068019148C71924100 @default.
• W2068019148 hasConceptScore W2068019148C98274493 @default.
• W2068019148 hasIssue "2" @default.
• W2068019148 hasLocation W20680191481 @default.
• W2068019148 hasLocation W20680191482 @default.
• W2068019148 hasLocation W20680191483 @default.
• W2068019148 hasOpenAccess W2068019148 @default.
• W2068019148 hasPrimaryLocation W20680191481 @default.
• W2068019148 hasRelatedWork W2040789109 @default.
• W2068019148 hasRelatedWork W2064786341 @default.
• W2068019148 hasRelatedWork W2071070793 @default.

• next