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- W2068022369 abstract "Recordings of noxious intra-arterial bradykinin (BK)-induced chemonociceptive and spontaneous activity from 30 single spinal lamina V neurones of the dorsal horns in non-anaesthetized and decerebrated rabbits, were performed with tungsten microelectrodes. Intravenous injection of midazolam (0.2 mgkg; 7 neurones) depressed BK-induced neural discharges by 55.0 ± 6.2% (P < 0.05) and 57.9 ± 8.4% (P < 0.05) 5 and 25 min after administration, respectively. Treatment with flumazenil (0.2 mgkg, i.V.; 7 neurones), administered 20 min after midazolam, completely reversed the inhibition by midazolam of the BK-induced spinal lamina V neural responses and spontaneous neuronal activity. In contrast, a large dose of naloxone (1.0 mgkg, i.V.; 6 neurones), administered 20 min after midazolam, failed to alter the midazolam-induced depressant effects on the nociceptive responses, at the spinal dorsal horn. Treatments with flumazenil (5 neurones) and naloxone (5 neurones) did not influence either the spontaneous or the BK-induced neuronal discharges, recorded in spinal lamina V cells. Midazolam depressed the nociceptive responses probably through its agonistic activity on the binding to the GABA-benzodiazepine-barbiturate system in the spinal dorsal horn." @default.
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- W2068022369 date "1992-01-01" @default.
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- W2068022369 title "Suppressant effects of midazolam on responses of spinal dorsal horn neurones in rabbits" @default.
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- W2068022369 doi "https://doi.org/10.1016/0028-3908(92)90160-q" @default.
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