Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068030385> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2068030385 endingPage "441" @default.
- W2068030385 startingPage "437" @default.
- W2068030385 abstract "In breast cancer, axillary lymph node invasiveness is the major prognostic factor in predicting relapse and metastasis. Nevertheless, since 30% of node-negative tumors also relapse, it is necessary to develop other independent prognostic factors. Oncogene amplification and the level of cathepsin D (cath-D), an acidic lysosomal protease produced and secreted in excess by breast cancer cells, have been proposed as additional prognostic factors. We have compared the cytosolic cath-D level and the amplification of three oncogenes: c-myc, neu-erb-B-2 and int-2 in 140 primary breast carcinomas and 64 axillary lymph nodes collected in 1987 and 1988 at the Cancer Center of Montpellier (Centre Paul Lamarque). None of the patients had previously received hormonal or chemotherapy. The cath-D concentration was measured with an immunoradiometric assay using monoclonal antibodies. DNA purified from the same samples was analyzed by a standard Southern blotting technique to estimate oncogene amplification. No correlation was found between the level of cath-D in the tumor and node invasiveness. Using a cut-off level of 60 pmol/mg protein, the status of cath-D was not correlated with neu-erb-B-2 and int-2 amplification and only correlated with c-myc amplification (P = 0.011). Both c-myc and cath-D are associated with cell proliferation, induced by estrogens in ER+ breast cancer, and constitutively produced in ER- breast cancer. The level of cath-D was significantly higher in the invaded lymph nodes (P = 0.04) than in the histologically non-invaded ones. Nevertheless, some non-invaded lymph nodes contained a high level of cath-D, as confirmed by immunoperoxidase staining. In conclusion, in breast cancer, a high cytosolic cath-D concentration is more frequent in tumors with c-myc amplification but is dissociated from neu-erb-B-2 or int-2 amplification, suggesting that the determination of these three markers will have an additional prognostic value." @default.
- W2068030385 created "2016-06-24" @default.
- W2068030385 creator A5018555679 @default.
- W2068030385 creator A5019839327 @default.
- W2068030385 creator A5020771786 @default.
- W2068030385 creator A5025271863 @default.
- W2068030385 creator A5028773358 @default.
- W2068030385 creator A5031089086 @default.
- W2068030385 creator A5034959128 @default.
- W2068030385 creator A5057927427 @default.
- W2068030385 creator A5082578710 @default.
- W2068030385 date "1990-04-01" @default.
- W2068030385 modified "2023-10-18" @default.
- W2068030385 title "Cathepsin D assay in primary breast cancer and lymph nodes: Relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness" @default.
- W2068030385 cites W1494515794 @default.
- W2068030385 cites W1944038918 @default.
- W2068030385 cites W1968322556 @default.
- W2068030385 cites W2012855221 @default.
- W2068030385 cites W2017001433 @default.
- W2068030385 cites W2022007118 @default.
- W2068030385 cites W2057131341 @default.
- W2068030385 cites W2074548631 @default.
- W2068030385 cites W2141393790 @default.
- W2068030385 cites W2142617031 @default.
- W2068030385 cites W2160895353 @default.
- W2068030385 cites W2322326756 @default.
- W2068030385 cites W2339389593 @default.
- W2068030385 cites W2426150444 @default.
- W2068030385 cites W4252886232 @default.
- W2068030385 doi "https://doi.org/10.1016/0277-5379(90)90012-i" @default.
- W2068030385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2141510" @default.
- W2068030385 hasPublicationYear "1990" @default.
- W2068030385 type Work @default.
- W2068030385 sameAs 2068030385 @default.
- W2068030385 citedByCount "83" @default.
- W2068030385 countsByYear W20680303852013 @default.
- W2068030385 countsByYear W20680303852019 @default.
- W2068030385 crossrefType "journal-article" @default.
- W2068030385 hasAuthorship W2068030385A5018555679 @default.
- W2068030385 hasAuthorship W2068030385A5019839327 @default.
- W2068030385 hasAuthorship W2068030385A5020771786 @default.
- W2068030385 hasAuthorship W2068030385A5025271863 @default.
- W2068030385 hasAuthorship W2068030385A5028773358 @default.
- W2068030385 hasAuthorship W2068030385A5031089086 @default.
- W2068030385 hasAuthorship W2068030385A5034959128 @default.
- W2068030385 hasAuthorship W2068030385A5057927427 @default.
- W2068030385 hasAuthorship W2068030385A5082578710 @default.
- W2068030385 hasConcept C121608353 @default.
- W2068030385 hasConcept C126322002 @default.
- W2068030385 hasConcept C142724271 @default.
- W2068030385 hasConcept C173633252 @default.
- W2068030385 hasConcept C181199279 @default.
- W2068030385 hasConcept C2779013556 @default.
- W2068030385 hasConcept C2780849966 @default.
- W2068030385 hasConcept C2781018059 @default.
- W2068030385 hasConcept C29537977 @default.
- W2068030385 hasConcept C502942594 @default.
- W2068030385 hasConcept C530470458 @default.
- W2068030385 hasConcept C55493867 @default.
- W2068030385 hasConcept C71924100 @default.
- W2068030385 hasConcept C86803240 @default.
- W2068030385 hasConceptScore W2068030385C121608353 @default.
- W2068030385 hasConceptScore W2068030385C126322002 @default.
- W2068030385 hasConceptScore W2068030385C142724271 @default.
- W2068030385 hasConceptScore W2068030385C173633252 @default.
- W2068030385 hasConceptScore W2068030385C181199279 @default.
- W2068030385 hasConceptScore W2068030385C2779013556 @default.
- W2068030385 hasConceptScore W2068030385C2780849966 @default.
- W2068030385 hasConceptScore W2068030385C2781018059 @default.
- W2068030385 hasConceptScore W2068030385C29537977 @default.
- W2068030385 hasConceptScore W2068030385C502942594 @default.
- W2068030385 hasConceptScore W2068030385C530470458 @default.
- W2068030385 hasConceptScore W2068030385C55493867 @default.
- W2068030385 hasConceptScore W2068030385C71924100 @default.
- W2068030385 hasConceptScore W2068030385C86803240 @default.
- W2068030385 hasIssue "4" @default.
- W2068030385 hasLocation W20680303851 @default.
- W2068030385 hasLocation W20680303852 @default.
- W2068030385 hasOpenAccess W2068030385 @default.
- W2068030385 hasPrimaryLocation W20680303851 @default.
- W2068030385 hasRelatedWork W1499339123 @default.
- W2068030385 hasRelatedWork W1975859778 @default.
- W2068030385 hasRelatedWork W2042520059 @default.
- W2068030385 hasRelatedWork W2758639219 @default.
- W2068030385 hasRelatedWork W2762132287 @default.
- W2068030385 hasRelatedWork W2792929645 @default.
- W2068030385 hasRelatedWork W2803841817 @default.
- W2068030385 hasRelatedWork W2904294837 @default.
- W2068030385 hasRelatedWork W2989955996 @default.
- W2068030385 hasRelatedWork W3173207637 @default.
- W2068030385 hasVolume "26" @default.
- W2068030385 isParatext "false" @default.
- W2068030385 isRetracted "false" @default.
- W2068030385 magId "2068030385" @default.
- W2068030385 workType "article" @default.