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- W2068034211 abstract "The DNA extracted from chicken cells transformed by the ts-LA335 mutant of Rous sarcoma virus (RSV) gave rise, in transfection experiments, to transforming viruses. These viruses exhibited a temperature-sensitive lesion in early functions similar to that characteristic of the LA335 mutant. One of the recovered viruses was further examined for a DNA polymerase activity at permissive and nonpermissive temperatures and was found to carry an enzyme resembling, with respect to thermosensitivity, the DNA polymerase of the parent LA335 mutant. It was concluded that the infectious viral DNA extracted from RSV-transformed cells carries the genetic information for the DNA polymerase specific for the parent virus. This information is transferred, upon transfection of permissive cells, to the progeny virus." @default.
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- W2068034211 date "1975-09-01" @default.
- W2068034211 modified "2023-10-17" @default.
- W2068034211 title "Infectious DNA coding for a temperature-sensitive DNA polymerase of the coordinate LA335 mutant of Rous sarcoma virus (RSV)" @default.
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- W2068034211 doi "https://doi.org/10.1016/0042-6822(75)90428-6" @default.
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