FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068034454> ?p ?o ?g. }

• W2068034454 endingPage "231" @default.
• W2068034454 startingPage "200" @default.
• W2068034454 abstract "Gene translation is a central process in all living organism with important ramifications to almost every biomedical field. Previous systems evolutionary studies in the field have demonstrated that in many organisms coding sequence features undergo selection to optimize this process. In the current study, we report for the first time analytical proofs related to the various aspects of this process and its optimality. Among our results we show that coding sequences with mono- tonic increasing profiles of translation efficiency (i.e., with slower codons near the 5′UTR), mathematically optimize ribosomal allocation by minimizing the number of ribosomes needed for translating a codon per time unit. Thus, the genomic translation efficiency profile reported in previous studies for many organisms is optimal in this sense. In addition, we show that improving translation efficiency of a codon in a gene may result in a decrease in the translation rate of other genes, demonstrating that the relation between codon bias and protein translation rate is less trivial than was assumed before. Based on these observations we describe an efficient heuristic for designing coding sequences with specific translation efficiency and minimal ribosomal allocation for heterologous gene expression. We demonstrate how this heuristic can be used in biotechnology for engineering a heterologous gene before expressing it in a new host." @default.
• W2068034454 created "2016-06-24" @default.
• W2068034454 creator A5021278923 @default.
• W2068034454 creator A5039592727 @default.
• W2068034454 date "2012-02-01" @default.
• W2068034454 modified "2023-10-11" @default.
• W2068034454 title "Efficient Manipulations of Synonymous Mutations for Controlling Translation Rate: An Analytical Approach" @default.
• W2068034454 cites W1550695177 @default.
• W2068034454 cites W1971453673 @default.
• W2068034454 cites W1976515682 @default.
• W2068034454 cites W1983438661 @default.
• W2068034454 cites W1993009001 @default.
• W2068034454 cites W2003514067 @default.
• W2068034454 cites W2018590530 @default.
• W2068034454 cites W2019604065 @default.
• W2068034454 cites W2020138003 @default.
• W2068034454 cites W2025569664 @default.
• W2068034454 cites W2027412279 @default.
• W2068034454 cites W2034108516 @default.
• W2068034454 cites W2045348184 @default.
• W2068034454 cites W2045882517 @default.
• W2068034454 cites W2051242197 @default.
• W2068034454 cites W2053460598 @default.
• W2068034454 cites W2063779182 @default.
• W2068034454 cites W2066829062 @default.
• W2068034454 cites W2072499238 @default.
• W2068034454 cites W2076034830 @default.
• W2068034454 cites W2076278017 @default.
• W2068034454 cites W2078146553 @default.
• W2068034454 cites W2078755055 @default.
• W2068034454 cites W2079517684 @default.
• W2068034454 cites W2079650808 @default.
• W2068034454 cites W2082317854 @default.
• W2068034454 cites W2086471971 @default.
• W2068034454 cites W2086665421 @default.
• W2068034454 cites W2092846883 @default.
• W2068034454 cites W2122438081 @default.
• W2068034454 cites W2129178024 @default.
• W2068034454 cites W2148627082 @default.
• W2068034454 cites W2151102421 @default.
• W2068034454 cites W2166752189 @default.
• W2068034454 cites W2167868583 @default.
• W2068034454 doi "https://doi.org/10.1089/cmb.2011.0275" @default.
• W2068034454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22300321" @default.
• W2068034454 hasPublicationYear "2012" @default.
• W2068034454 type Work @default.
• W2068034454 sameAs 2068034454 @default.
• W2068034454 citedByCount "30" @default.
• W2068034454 countsByYear W20680344542012 @default.
• W2068034454 countsByYear W20680344542013 @default.
• W2068034454 countsByYear W20680344542014 @default.
• W2068034454 countsByYear W20680344542015 @default.
• W2068034454 countsByYear W20680344542016 @default.
• W2068034454 countsByYear W20680344542017 @default.
• W2068034454 countsByYear W20680344542018 @default.
• W2068034454 countsByYear W20680344542019 @default.
• W2068034454 countsByYear W20680344542020 @default.
• W2068034454 countsByYear W20680344542021 @default.
• W2068034454 countsByYear W20680344542022 @default.
• W2068034454 crossrefType "journal-article" @default.
• W2068034454 hasAuthorship W2068034454A5021278923 @default.
• W2068034454 hasAuthorship W2068034454A5039592727 @default.
• W2068034454 hasConcept C104317684 @default.
• W2068034454 hasConcept C105580179 @default.
• W2068034454 hasConcept C141231307 @default.
• W2068034454 hasConcept C149364088 @default.
• W2068034454 hasConcept C154945302 @default.
• W2068034454 hasConcept C173801870 @default.
• W2068034454 hasConcept C2775992057 @default.
• W2068034454 hasConcept C41008148 @default.
• W2068034454 hasConcept C54355233 @default.
• W2068034454 hasConcept C67705224 @default.
• W2068034454 hasConcept C70721500 @default.
• W2068034454 hasConcept C86803240 @default.
• W2068034454 hasConcept C87253356 @default.
• W2068034454 hasConcept C88478588 @default.
• W2068034454 hasConcept C91779695 @default.
• W2068034454 hasConceptScore W2068034454C104317684 @default.
• W2068034454 hasConceptScore W2068034454C105580179 @default.
• W2068034454 hasConceptScore W2068034454C141231307 @default.
• W2068034454 hasConceptScore W2068034454C149364088 @default.
• W2068034454 hasConceptScore W2068034454C154945302 @default.
• W2068034454 hasConceptScore W2068034454C173801870 @default.
• W2068034454 hasConceptScore W2068034454C2775992057 @default.
• W2068034454 hasConceptScore W2068034454C41008148 @default.
• W2068034454 hasConceptScore W2068034454C54355233 @default.
• W2068034454 hasConceptScore W2068034454C67705224 @default.
• W2068034454 hasConceptScore W2068034454C70721500 @default.
• W2068034454 hasConceptScore W2068034454C86803240 @default.
• W2068034454 hasConceptScore W2068034454C87253356 @default.
• W2068034454 hasConceptScore W2068034454C88478588 @default.
• W2068034454 hasConceptScore W2068034454C91779695 @default.
• W2068034454 hasIssue "2" @default.
• W2068034454 hasLocation W20680344541 @default.
• W2068034454 hasLocation W20680344542 @default.
• W2068034454 hasOpenAccess W2068034454 @default.
• W2068034454 hasPrimaryLocation W20680344541 @default.
• W2068034454 hasRelatedWork W1790958488 @default.

• next