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- W2068034489 abstract "The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular matrix itself plays a central role in coordinating these signaling processes. In this review, we consider the interrelationships between the extracellular matrix, integrins, growth factors, and steroid hormones in mammary gland development and function." @default.
- W2068034489 created "2016-06-24" @default.
- W2068034489 creator A5090212278 @default.
- W2068034489 creator A5091003294 @default.
- W2068034489 date "2000-06-01" @default.
- W2068034489 modified "2023-09-25" @default.
- W2068034489 title "Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones." @default.
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