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- W2068034651 abstract "We performed I-123-IMP SPECT brain imaging on seven mildly demented AIDS patients and seven normal subjects. In an attempt to detect and quantitate regions of decreased I-123-IMP uptake, pixel intensity histograms of normalized SPECT images at the basal ganglia level were analyzed for the fraction of pixels in the lowest quartile of the intensity range. This fraction (F) averaged 17.5% (S.D. = 4.6) in the AIDS group and 12.6% (S.D. = 5.1) in the normal group (p less than .05). Six of the AIDS patients underwent neuropsychological testing (NPT). NPT showed the patients to have a variety of mild abnormalities. Regression analysis of NPT scores versus F yielded a correlation coefficient of .80 (p less than .05). We conclude that analysis of I-123-IMP SPECT image pixel intensity distribution is potentially sensitive in detecting abnormalities associated with AIDS dementia and may correlate with the severity of dementia as measured by NPT." @default.
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- W2068034651 date "1990-12-01" @default.
- W2068034651 modified "2023-09-24" @default.
- W2068034651 title "QUANTITATIVE I-123-IMP BRAIN SPECT AND NEUROPSYCHOLOGICAL TESTING IN AIDS DEMENTIA" @default.
- W2068034651 doi "https://doi.org/10.1097/00004424-199012000-00140" @default.
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