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- W2068038523 abstract "Understanding of cytotoxic T cell recognition may be relevant to the study of drug-related lupus because either cell-mediated cytotoxicity (CMC) contributes to triggering the disease or CMC provides an informative model to study T cell recognition of foreign antigen. As a model, CMC demonstrates the following: 1) Antigen presentation can occur by membrane insertion of the antigen, covalent modification of the cell surface, or cell surface adsorption of the antigen; these may be modes of presentation by which drug-related antigens induce adverse responses. 2) HLA antigens regulate a wide variety of immune responses; this may be crucial in drug-related lupus since HLA antigens may regulate autoimmune responses, may affect an individual' susceptibility to lupus, and may increase the risk for other specific adverse drug reactions." @default.
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- W2068038523 date "1981-08-01" @default.
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- W2068038523 title "Cytotoxic T cell interactions with antigen. potential relevance for drug-related lupus" @default.
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- W2068038523 doi "https://doi.org/10.1002/art.1780240809" @default.
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