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- W2068038734 abstract "The sudden, late appearance of multiple complications and the autopsy demonstration of a newly recognized side effect, ovarian destruction, are described in a young girl treated for a prolonged period with cyclophosphamide. She suffered the nearly simultaneous appearance of Pneumocystis carinii pneumonia and severe urinary tract hemorrhage in the twenty-ninth month of therapy. At autopsy, the ovaries were found to be totally lacking in ova or follicles, although the child was known to have had a normal XX chromosomal constitution. We believe that the ovarian disease observed in this case is the lesion associated with the amenorrhea which has recently been reported to occur during prolonged cyclophosphamide therapy in adults." @default.
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- W2068038734 date "1971-04-01" @default.
- W2068038734 modified "2023-10-03" @default.
- W2068038734 title "Multiple late complications of therapy with cyclophosphamide, including ovarian destruction" @default.
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- W2068038734 doi "https://doi.org/10.1016/0002-9343(71)90341-x" @default.
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