FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068040591> ?p ?o ?g. }

• W2068040591 endingPage "400" @default.
• W2068040591 startingPage "392" @default.
• W2068040591 abstract "Glucuronoxylomannan (GXM) is the major Cryptococcus neoformans capsular polysaccharide and represents the main virulence factor of this fungus. In in vitro studies we have demonstrated previously that this acidic and high-molecular-weight polysaccharide suppresses lymphoproliferation, modulates cytokine production and promotes apoptosis in spleen mononuclear (Spm) cells from rats. In this study we demonstrate that these phenomena also occur in vivo after the intracardiac inoculation of GXM into normal Wistar rats. The results of this study show suppression of the proliferative response Spm cells to concanavalin A (Con A) or heat-killed C. neoformans (HKCn) in the first 2 weeks after polysaccharide administration. In addition, increased levels of interleukin (IL)-10 were produced by Con A-stimulated Spm cells, coinciding with immunohistochemical GXM detection in the white pulp of spleen. In particular, high production of IL-10 with diminution of IL-2, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha synthesis were detected 14 days after GXM administration. In situ cell death detection by TdT-mediated biotin-dUTP nick-end labelling (TUNEL) reaction in sections of spleen, lung and liver demonstrates apoptosis in tissues with deposits of GXM. These data demonstrate the in vivo ability of GXM to modify cytokine synthesis by Spm cells and to promote host cell apoptosis." @default.
• W2068040591 created "2016-06-24" @default.
• W2068040591 creator A5014505825 @default.
• W2068040591 creator A5018470223 @default.
• W2068040591 creator A5030112526 @default.
• W2068040591 creator A5033069942 @default.
• W2068040591 creator A5061198315 @default.
• W2068040591 creator A5070716553 @default.
• W2068040591 date "2004-11-01" @default.
• W2068040591 modified "2023-10-17" @default.
• W2068040591 title "Immunosuppression, interleukin-10 synthesis and apoptosis are induced in rats inoculated with Cryptococcus neoformans glucuronoxylomannan" @default.
• W2068040591 cites W125353669 @default.
• W2068040591 cites W1559303214 @default.
• W2068040591 cites W1603466950 @default.
• W2068040591 cites W1712993486 @default.
• W2068040591 cites W1894665538 @default.
• W2068040591 cites W1933113401 @default.
• W2068040591 cites W1944932482 @default.
• W2068040591 cites W1948394619 @default.
• W2068040591 cites W1949975351 @default.
• W2068040591 cites W1957937071 @default.
• W2068040591 cites W1965259865 @default.
• W2068040591 cites W1968834637 @default.
• W2068040591 cites W1968862389 @default.
• W2068040591 cites W1990871997 @default.
• W2068040591 cites W1992573195 @default.
• W2068040591 cites W1998286686 @default.
• W2068040591 cites W2000191410 @default.
• W2068040591 cites W2007766909 @default.
• W2068040591 cites W2013394942 @default.
• W2068040591 cites W2025599602 @default.
• W2068040591 cites W2031207426 @default.
• W2068040591 cites W2034739355 @default.
• W2068040591 cites W2041247111 @default.
• W2068040591 cites W2043466117 @default.
• W2068040591 cites W2057967069 @default.
• W2068040591 cites W2062471925 @default.
• W2068040591 cites W2063818626 @default.
• W2068040591 cites W2065003627 @default.
• W2068040591 cites W2070566916 @default.
• W2068040591 cites W2088069787 @default.
• W2068040591 cites W2090554701 @default.
• W2068040591 cites W2097671773 @default.
• W2068040591 cites W2098163008 @default.
• W2068040591 cites W2099198339 @default.
• W2068040591 cites W2101141539 @default.
• W2068040591 cites W2105342913 @default.
• W2068040591 cites W2108461480 @default.
• W2068040591 cites W2113619398 @default.
• W2068040591 cites W2113948988 @default.
• W2068040591 cites W2118523249 @default.
• W2068040591 cites W2121344649 @default.
• W2068040591 cites W2127330103 @default.
• W2068040591 cites W2127693811 @default.
• W2068040591 cites W2132345749 @default.
• W2068040591 cites W2138302361 @default.
• W2068040591 cites W2142253178 @default.
• W2068040591 cites W2146101993 @default.
• W2068040591 cites W2151657112 @default.
• W2068040591 cites W2153072794 @default.
• W2068040591 cites W2162644900 @default.
• W2068040591 cites W2171166905 @default.
• W2068040591 cites W2234274735 @default.
• W2068040591 cites W2315224357 @default.
• W2068040591 cites W2332663809 @default.
• W2068040591 cites W2336331516 @default.
• W2068040591 cites W2444449052 @default.
• W2068040591 cites W2887435065 @default.
• W2068040591 cites W4250660039 @default.
• W2068040591 cites W5923498 @default.
• W2068040591 doi "https://doi.org/10.1111/j.1365-2567.2004.01970.x" @default.
• W2068040591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1782585" @default.
• W2068040591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15500627" @default.
• W2068040591 hasPublicationYear "2004" @default.
• W2068040591 type Work @default.
• W2068040591 sameAs 2068040591 @default.
• W2068040591 citedByCount "36" @default.
• W2068040591 countsByYear W20680405912012 @default.
• W2068040591 countsByYear W20680405912013 @default.
• W2068040591 countsByYear W20680405912015 @default.
• W2068040591 countsByYear W20680405912016 @default.
• W2068040591 countsByYear W20680405912018 @default.
• W2068040591 countsByYear W20680405912019 @default.
• W2068040591 countsByYear W20680405912020 @default.
• W2068040591 countsByYear W20680405912021 @default.
• W2068040591 countsByYear W20680405912022 @default.
• W2068040591 countsByYear W20680405912023 @default.
• W2068040591 crossrefType "journal-article" @default.
• W2068040591 hasAuthorship W2068040591A5014505825 @default.
• W2068040591 hasAuthorship W2068040591A5018470223 @default.
• W2068040591 hasAuthorship W2068040591A5030112526 @default.
• W2068040591 hasAuthorship W2068040591A5033069942 @default.
• W2068040591 hasAuthorship W2068040591A5061198315 @default.
• W2068040591 hasAuthorship W2068040591A5070716553 @default.
• W2068040591 hasBestOaLocation W20680405912 @default.
• W2068040591 hasConcept C17991360 @default.
• W2068040591 hasConcept C190283241 @default.
• W2068040591 hasConcept C196795494 @default.

• next