FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068040891> ?p ?o ?g. }

• W2068040891 endingPage "1212" @default.
• W2068040891 startingPage "1205" @default.
• W2068040891 abstract "We recently showed that patients with mitochondrial diabetes are insulin resistant in skeletal muscle before the decline in insulin secretion is observed. In this study, we further evaluate whether insulin resistance is associated with increased ectopic fat accumulation and altered adipose and hepatic tissue insulin sensitivity. We studied 15 nonobese patients with the m.3243A > G mutation. Five were without diabetes (group 1), three had newly diagnosed diabetes (group 2), and seven had previously diagnosed diabetes (group 3). Thirteen healthy volunteers of similar age and body mass index (BMI) served as controls. Insulin-stimulated glucose uptake was measured with positron emission tomography using 2- [(18)F]-fluoro-2-deoxyglucose during euglycemic hyperinsulinemia. Fat masses and liver fat content were measured with magnetic resonance imaging and spectroscopy. Compared with controls, insulin-stimulated glucose uptake in adipose tissue was decreased by ∼50% in all groups with the m.3243A > G mutation. In addition, fat masses were not different, but insulin-mediated suppression of lipolysis and adiponectin metabolism were blunted in patients with the m.3243A > G mutation. Hepatic fat content was normal (<5.6%) in 80% of patients and significantly elevated in one case only. Hepatic glucose metabolism in patients with m.3243A > G did not differ from that of controls. In conclusion, m.3243A > G mutation affects subcutaneous adipose tissue metabolism. This seems to occur before aberrant liver metabolism, if any, can be observed or before beta-cell failure results in mitochondrial diabetes." @default.
• W2068040891 created "2016-06-24" @default.
• W2068040891 creator A5017694686 @default.
• W2068040891 creator A5022006640 @default.
• W2068040891 creator A5038203474 @default.
• W2068040891 creator A5040232521 @default.
• W2068040891 creator A5040337251 @default.
• W2068040891 creator A5044512666 @default.
• W2068040891 creator A5065855094 @default.
• W2068040891 creator A5068279800 @default.
• W2068040891 creator A5081986241 @default.
• W2068040891 creator A5083467545 @default.
• W2068040891 date "2011-05-10" @default.
• W2068040891 modified "2023-09-25" @default.
• W2068040891 title "Mitochondrial diabetes is associated with insulin resistance in subcutaneous adipose tissue but not with increased liver fat content" @default.
• W2068040891 cites W1960953991 @default.
• W2068040891 cites W1965814437 @default.
• W2068040891 cites W1969675418 @default.
• W2068040891 cites W2004927761 @default.
• W2068040891 cites W2005084565 @default.
• W2068040891 cites W2006082012 @default.
• W2068040891 cites W2015711048 @default.
• W2068040891 cites W2019509271 @default.
• W2068040891 cites W2022138763 @default.
• W2068040891 cites W2024530489 @default.
• W2068040891 cites W2028441056 @default.
• W2068040891 cites W2038374115 @default.
• W2068040891 cites W2041499307 @default.
• W2068040891 cites W2047210179 @default.
• W2068040891 cites W2056236310 @default.
• W2068040891 cites W2066447432 @default.
• W2068040891 cites W2066599360 @default.
• W2068040891 cites W2067983165 @default.
• W2068040891 cites W2071867050 @default.
• W2068040891 cites W2076310317 @default.
• W2068040891 cites W2076380935 @default.
• W2068040891 cites W2087941994 @default.
• W2068040891 cites W2096629763 @default.
• W2068040891 cites W2101260083 @default.
• W2068040891 cites W2107503521 @default.
• W2068040891 cites W2116727306 @default.
• W2068040891 cites W2122623377 @default.
• W2068040891 cites W2139467028 @default.
• W2068040891 cites W2145177422 @default.
• W2068040891 cites W2146528609 @default.
• W2068040891 cites W2150547701 @default.
• W2068040891 cites W2153461284 @default.
• W2068040891 cites W2159469729 @default.
• W2068040891 cites W2170719669 @default.
• W2068040891 doi "https://doi.org/10.1007/s10545-011-9338-0" @default.
• W2068040891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21556834" @default.
• W2068040891 hasPublicationYear "2011" @default.
• W2068040891 type Work @default.
• W2068040891 sameAs 2068040891 @default.
• W2068040891 citedByCount "8" @default.
• W2068040891 countsByYear W20680408912014 @default.
• W2068040891 countsByYear W20680408912016 @default.
• W2068040891 countsByYear W20680408912019 @default.
• W2068040891 countsByYear W20680408912021 @default.
• W2068040891 crossrefType "journal-article" @default.
• W2068040891 hasAuthorship W2068040891A5017694686 @default.
• W2068040891 hasAuthorship W2068040891A5022006640 @default.
• W2068040891 hasAuthorship W2068040891A5038203474 @default.
• W2068040891 hasAuthorship W2068040891A5040232521 @default.
• W2068040891 hasAuthorship W2068040891A5040337251 @default.
• W2068040891 hasAuthorship W2068040891A5044512666 @default.
• W2068040891 hasAuthorship W2068040891A5065855094 @default.
• W2068040891 hasAuthorship W2068040891A5068279800 @default.
• W2068040891 hasAuthorship W2068040891A5081986241 @default.
• W2068040891 hasAuthorship W2068040891A5083467545 @default.
• W2068040891 hasConcept C126322002 @default.
• W2068040891 hasConcept C134018914 @default.
• W2068040891 hasConcept C140985366 @default.
• W2068040891 hasConcept C17093226 @default.
• W2068040891 hasConcept C171089720 @default.
• W2068040891 hasConcept C2776782570 @default.
• W2068040891 hasConcept C2777180221 @default.
• W2068040891 hasConcept C2777391703 @default.
• W2068040891 hasConcept C2779306644 @default.
• W2068040891 hasConcept C2780988686 @default.
• W2068040891 hasConcept C555293320 @default.
• W2068040891 hasConcept C71924100 @default.
• W2068040891 hasConcept C86803240 @default.
• W2068040891 hasConceptScore W2068040891C126322002 @default.
• W2068040891 hasConceptScore W2068040891C134018914 @default.
• W2068040891 hasConceptScore W2068040891C140985366 @default.
• W2068040891 hasConceptScore W2068040891C17093226 @default.
• W2068040891 hasConceptScore W2068040891C171089720 @default.
• W2068040891 hasConceptScore W2068040891C2776782570 @default.
• W2068040891 hasConceptScore W2068040891C2777180221 @default.
• W2068040891 hasConceptScore W2068040891C2777391703 @default.
• W2068040891 hasConceptScore W2068040891C2779306644 @default.
• W2068040891 hasConceptScore W2068040891C2780988686 @default.
• W2068040891 hasConceptScore W2068040891C555293320 @default.
• W2068040891 hasConceptScore W2068040891C71924100 @default.
• W2068040891 hasConceptScore W2068040891C86803240 @default.
• W2068040891 hasIssue "6" @default.
• W2068040891 hasLocation W20680408911 @default.

• next