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• W2068042695 abstract "<b><i>Background:</i></b> Epidemiological studies suggest that vitamin D may be protective against the inception and exacerbation of allergic diseases. However, the direct effect of vitamin D on eosinophils, the major effector cells in allergic inflammation, is not known. It has been reported that C-X-C chemokine receptor type 4 (CXCR4) in eosinophils is induced in non-Th2 cytokine milieu or in response to glucocorticoids, recruiting the cell to noninflammatory sites. <b><i>Objectives:</i></b> To test whether 1,25-dihydroxyvitamin D₃ [1,25-(OH)₂D₃ or calcitriol], the active metabolite of vitamin D, acts directly on eosinophils to induce upregulation of CXCR4. <b><i>Methods:</i></b> Peripheral blood eosinophils from normal volunteers were isolated by CD16 immunomagnetic beads. Vitamin D receptor (VDR) expression was detected by RT-PCR. Eosinophils were cultured with 1,25-(OH)₂D₃ and the survival and expression of CXCR4 on eosinophils were measured by flowcytometry. Eosinophil migration by CXCL-12/SDF-1 in the presence of 1,25-(OH)₂D₃ was also analyzed. <b><i>Results:</i></b> Eosinophils expressed VDR. 1,25-(OH)₂D₃ prolonged eosinophil survival and upregulated eosinophil surface expression of CXCR4 in a concentration-dependent manner. Interleukin (IL)-5 significantly reduced CXCR4 expression and migration induced by the ligand CXCL-12/SDF-1. 1,25-(OH)₂D₃ reversed the negative effects of IL-5 on the CXCR4-CXCL12 pathway. <b><i>Conclusion:</i></b> 1,25-(OH)₂D₃ regulates CXCR4 expression in eosinophils. The mechanism may be involved in eosinophil recruitment to noninflammatory sites where the ligand of CXCR4 is constitutively expressed." @default.
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• W2068042695 date "2012-01-01" @default.
• W2068042695 modified "2023-09-24" @default.
• W2068042695 title "1,25-Dihydroxyvitamin D₃ Upregulates Functional C-X-C Chemokine Receptor Type 4 Expression in Human Eosinophils" @default.
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• W2068042695 doi "https://doi.org/10.1159/000337767" @default.
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