FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068043241> ?p ?o ?g. }

• W2068043241 endingPage "1486" @default.
• W2068043241 startingPage "1478" @default.
• W2068043241 abstract "The pathological processes of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases engender synaptic and neuronal cell damage. While mild oxidative and nitrosative (nitric oxide (NO)-related) stress mediates normal neuronal signaling, excessive accumulation of these free radicals is linked to neuronal cell injury or death. In neurons, N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation and subsequent Ca2+ influx can induce the generation of NO via neuronal NO synthase. Emerging evidence has demonstrated that S-nitrosylation, representing covalent reaction of an NO group with a critical protein thiol, mediates the vast majority of NO signaling. Analogous to phosphorylation and other posttranslational modifications, S-nitrosylation can regulate the biological activity of many proteins. Here, we discuss recent studies that implicate neuropathogenic roles of S-nitrosylation in protein misfolding, mitochondrial dysfunction, synaptic injury, and eventual neuronal loss. Among a growing number of S-nitrosylated proteins that contribute to disease pathogenesis, in this review we focus on S-nitrosylated protein-disulfide isomerase (forming SNO-PDI) and dynamin-related protein 1 (forming SNO-Drp1). Furthermore, we describe drugs, such as memantine and newer derivatives of this compound that can prevent both hyperactivation of extrasynaptic NMDARs as well as downstream pathways that lead to nitrosative stress, synaptic damage, and neuronal loss." @default.
• W2068043241 created "2016-06-24" @default.
• W2068043241 creator A5066753734 @default.
• W2068043241 creator A5074186358 @default.
• W2068043241 date "2011-05-20" @default.
• W2068043241 modified "2023-10-06" @default.
• W2068043241 title "Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases" @default.
• W2068043241 cites W1269597682 @default.
• W2068043241 cites W1481263059 @default.
• W2068043241 cites W1504584187 @default.
• W2068043241 cites W1525431558 @default.
• W2068043241 cites W1528220495 @default.
• W2068043241 cites W1543601456 @default.
• W2068043241 cites W1547809857 @default.
• W2068043241 cites W1619234695 @default.
• W2068043241 cites W1729010372 @default.
• W2068043241 cites W1780139514 @default.
• W2068043241 cites W1887462983 @default.
• W2068043241 cites W1966923623 @default.
• W2068043241 cites W1967117930 @default.
• W2068043241 cites W1969199506 @default.
• W2068043241 cites W1970243208 @default.
• W2068043241 cites W1971335269 @default.
• W2068043241 cites W1974434733 @default.
• W2068043241 cites W1977535645 @default.
• W2068043241 cites W1978268445 @default.
• W2068043241 cites W1981238903 @default.
• W2068043241 cites W1987459699 @default.
• W2068043241 cites W1988726352 @default.
• W2068043241 cites W1988734169 @default.
• W2068043241 cites W1993385893 @default.
• W2068043241 cites W1996568613 @default.
• W2068043241 cites W1997211840 @default.
• W2068043241 cites W1999692038 @default.
• W2068043241 cites W2000742321 @default.
• W2068043241 cites W2002753297 @default.
• W2068043241 cites W2005675674 @default.
• W2068043241 cites W2006569015 @default.
• W2068043241 cites W2009013636 @default.
• W2068043241 cites W2012870439 @default.
• W2068043241 cites W2015902113 @default.
• W2068043241 cites W2019738475 @default.
• W2068043241 cites W2021727296 @default.
• W2068043241 cites W2022972602 @default.
• W2068043241 cites W2024674223 @default.
• W2068043241 cites W2024862570 @default.
• W2068043241 cites W2025405718 @default.
• W2068043241 cites W2025931796 @default.
• W2068043241 cites W2027275070 @default.
• W2068043241 cites W2032817175 @default.
• W2068043241 cites W2032879521 @default.
• W2068043241 cites W2033283296 @default.
• W2068043241 cites W2033851229 @default.
• W2068043241 cites W2037038958 @default.
• W2068043241 cites W2040852689 @default.
• W2068043241 cites W2044130121 @default.
• W2068043241 cites W2045085957 @default.
• W2068043241 cites W2047596252 @default.
• W2068043241 cites W2049805091 @default.
• W2068043241 cites W2051369940 @default.
• W2068043241 cites W2051653156 @default.
• W2068043241 cites W2052852525 @default.
• W2068043241 cites W2054240180 @default.
• W2068043241 cites W2054307806 @default.
• W2068043241 cites W2058289888 @default.
• W2068043241 cites W2062384458 @default.
• W2068043241 cites W2065773243 @default.
• W2068043241 cites W2066374288 @default.
• W2068043241 cites W2069288489 @default.
• W2068043241 cites W2071468228 @default.
• W2068043241 cites W2072329091 @default.
• W2068043241 cites W2082151254 @default.
• W2068043241 cites W2083134443 @default.
• W2068043241 cites W2085035881 @default.
• W2068043241 cites W2086313318 @default.
• W2068043241 cites W2089141103 @default.
• W2068043241 cites W2090466136 @default.
• W2068043241 cites W2093425025 @default.
• W2068043241 cites W2093935547 @default.
• W2068043241 cites W2094113524 @default.
• W2068043241 cites W2094645185 @default.
• W2068043241 cites W2097497116 @default.
• W2068043241 cites W2098548022 @default.
• W2068043241 cites W2104437967 @default.
• W2068043241 cites W2105043890 @default.
• W2068043241 cites W2105970121 @default.
• W2068043241 cites W2107366065 @default.
• W2068043241 cites W2107658086 @default.
• W2068043241 cites W2114881821 @default.
• W2068043241 cites W2120143950 @default.
• W2068043241 cites W2121104497 @default.
• W2068043241 cites W2127271204 @default.
• W2068043241 cites W2129899796 @default.
• W2068043241 cites W2133569747 @default.
• W2068043241 cites W2139290875 @default.
• W2068043241 cites W2142084126 @default.
• W2068043241 cites W2146204489 @default.
• W2068043241 cites W2164027831 @default.

• next