FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068044512> ?p ?o ?g. }

• W2068044512 endingPage "108" @default.
• W2068044512 startingPage "97" @default.
• W2068044512 abstract "The N-terminus of the type 1 interferon receptor subunit, IFNAR1, has high amino acid sequence similarity to the receptor binding B subunit of the Escherichia coli-derived verotoxin 1, VT1. The glycolipid, globotriaosyl ceramide (Gb(3): Gal alpha(1) --> 4 Gal beta 1 --> 4 Glu beta 1 --> 1 Cer) is the specific cell receptor for VT1. Gb(3)-deficient variant cells selected for VT resistance are cross-resistant to interferon-alpha (IFN-alpha)-mediated antiproliferative activity. The association of eIFNAR1 with Gal alpha 1 --> 4 Gal containing glycolipids has been previously shown to be important for the receptor-mediated IFN-alpha signal transduction for growth inhibition. The crucial role of Gb(3) for the signal transduction of IFN-alpha-mediated antiviral activity is now reported. IFN-alpha-mediated antiviral activity, nuclear translocation of activated Stat1, and increased expression of PKR were defective in Gb(3)-deficient vero mutant cells, although the surface expression of IFNAR1 was unaltered. The VT1B subunit was found to inhibit IFN-alpha-mediated antiviral activity, Stat1 nuclear translocation and PKR upregulation. Unlike VT1 cytotoxicity, IFN-alpha-induced Stat1 nuclear translocation was not inhibited when RME was prevented, suggesting that the accessory function of Gb(3) occurs at the plasma membrane. IFN-alpha antiviral activity was also studied in Gb(3)-positive MRC-5 cells, which are resistant to IFN-alpha growth inhibition, partially resistant to VT1 but still remain fully sensitive to IFN-alpha antiviral activity, and two astrocytoma cell lines expressing different Gb(3) fatty acid isoforms. In both systems, long chain fatty acid-containing Gb(3) isoforms, which are less effective to mediate VT1 cytotoxicity, were found to correlate with higher IFN-alpha-mediated antiviral activity. Inhibition of Gb(3) synthesis in toto prevented IFN-alpha antiviral activity in all cells. We propose that the long chain Gb(3) fatty isoforms preferentially remain in the plasma membrane, and by associating with IFNAR1, mediate IFN-alpha antiviral signaling, whereas short chain Gb(3) fatty acid isoforms are preferentially internalized to mediate VT1 cytotoxicity and IFNAR1-dependent IFN-alpha growth inhibition." @default.
• W2068044512 created "2016-06-24" @default.
• W2068044512 creator A5033073217 @default.
• W2068044512 creator A5072877385 @default.
• W2068044512 date "2000-01-01" @default.
• W2068044512 modified "2023-10-10" @default.
• W2068044512 title "Functional significance of globotriaosyl ceramide in interferon-?2/type 1 interferon receptor-mediated antiviral activity" @default.
• W2068044512 cites W1482533589 @default.
• W2068044512 cites W1597687278 @default.
• W2068044512 cites W1605500799 @default.
• W2068044512 cites W174927118 @default.
• W2068044512 cites W1864177015 @default.
• W2068044512 cites W1872694920 @default.
• W2068044512 cites W1925761535 @default.
• W2068044512 cites W1965398762 @default.
• W2068044512 cites W1969987939 @default.
• W2068044512 cites W1970936265 @default.
• W2068044512 cites W1975239369 @default.
• W2068044512 cites W1980081171 @default.
• W2068044512 cites W1990474286 @default.
• W2068044512 cites W1999650545 @default.
• W2068044512 cites W2000013726 @default.
• W2068044512 cites W2000392107 @default.
• W2068044512 cites W2008628754 @default.
• W2068044512 cites W2014903320 @default.
• W2068044512 cites W2030227166 @default.
• W2068044512 cites W2031708564 @default.
• W2068044512 cites W2034736009 @default.
• W2068044512 cites W2035688539 @default.
• W2068044512 cites W2048430637 @default.
• W2068044512 cites W2051256643 @default.
• W2068044512 cites W2053663046 @default.
• W2068044512 cites W2053922332 @default.
• W2068044512 cites W2077293253 @default.
• W2068044512 cites W2081350964 @default.
• W2068044512 cites W2083987209 @default.
• W2068044512 cites W2086433473 @default.
• W2068044512 cites W2112549075 @default.
• W2068044512 cites W2112809104 @default.
• W2068044512 cites W2118410712 @default.
• W2068044512 cites W2120341274 @default.
• W2068044512 cites W2121727262 @default.
• W2068044512 cites W2135110183 @default.
• W2068044512 cites W2138668166 @default.
• W2068044512 cites W2156080241 @default.
• W2068044512 cites W2177943720 @default.
• W2068044512 cites W2230628243 @default.
• W2068044512 cites W2253838792 @default.
• W2068044512 cites W2412539414 @default.
• W2068044512 cites W4298404236 @default.
• W2068044512 cites W84412087 @default.
• W2068044512 doi "https://doi.org/10.1002/(sici)1097-4652(200001)182:1<97::aid-jcp11>3.0.co;2-y" @default.
• W2068044512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10567921" @default.
• W2068044512 hasPublicationYear "2000" @default.
• W2068044512 type Work @default.
• W2068044512 sameAs 2068044512 @default.
• W2068044512 citedByCount "25" @default.
• W2068044512 countsByYear W20680445122014 @default.
• W2068044512 countsByYear W20680445122015 @default.
• W2068044512 countsByYear W20680445122018 @default.
• W2068044512 countsByYear W20680445122020 @default.
• W2068044512 countsByYear W20680445122021 @default.
• W2068044512 countsByYear W20680445122022 @default.
• W2068044512 countsByYear W20680445122023 @default.
• W2068044512 crossrefType "journal-article" @default.
• W2068044512 hasAuthorship W2068044512A5033073217 @default.
• W2068044512 hasAuthorship W2068044512A5072877385 @default.
• W2068044512 hasConcept C104292427 @default.
• W2068044512 hasConcept C104317684 @default.
• W2068044512 hasConcept C153911025 @default.
• W2068044512 hasConcept C159047783 @default.
• W2068044512 hasConcept C164083038 @default.
• W2068044512 hasConcept C170493617 @default.
• W2068044512 hasConcept C190283241 @default.
• W2068044512 hasConcept C2776178377 @default.
• W2068044512 hasConcept C2777851122 @default.
• W2068044512 hasConcept C2778278966 @default.
• W2068044512 hasConcept C2909179924 @default.
• W2068044512 hasConcept C55493867 @default.
• W2068044512 hasConcept C62478195 @default.
• W2068044512 hasConcept C83730767 @default.
• W2068044512 hasConcept C86803240 @default.
• W2068044512 hasConceptScore W2068044512C104292427 @default.
• W2068044512 hasConceptScore W2068044512C104317684 @default.
• W2068044512 hasConceptScore W2068044512C153911025 @default.
• W2068044512 hasConceptScore W2068044512C159047783 @default.
• W2068044512 hasConceptScore W2068044512C164083038 @default.
• W2068044512 hasConceptScore W2068044512C170493617 @default.
• W2068044512 hasConceptScore W2068044512C190283241 @default.
• W2068044512 hasConceptScore W2068044512C2776178377 @default.
• W2068044512 hasConceptScore W2068044512C2777851122 @default.
• W2068044512 hasConceptScore W2068044512C2778278966 @default.
• W2068044512 hasConceptScore W2068044512C2909179924 @default.
• W2068044512 hasConceptScore W2068044512C55493867 @default.
• W2068044512 hasConceptScore W2068044512C62478195 @default.
• W2068044512 hasConceptScore W2068044512C83730767 @default.
• W2068044512 hasConceptScore W2068044512C86803240 @default.
• W2068044512 hasIssue "1" @default.

• next