FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068045978> ?p ?o ?g. }

• W2068045978 endingPage "2356" @default.
• W2068045978 startingPage "2351" @default.
• W2068045978 abstract "Several cytogenetic abnormalities are associated with poor outcomes in multiple myeloma (MM). We prospectively analyzed the impact of cytogenetic abnormalities on outcomes during the phase 2 PX-171-003-A1 study of single-agent carfilzomib for relapsed and refractory MM. In the response-evaluable population (257/266), fluorescence in situ hybridization (FISH)/conventional cytogenetic profiles were available for 229 patients; 62 (27.1%) had high-risk cytogenetics--del 17p13, t(4;14) or t(14;16) by interphase FISH or deletion 13 or hypodiploidy by metaphase cytogenetics--and 167 (72.9%) had standard-risk profiles. Generally, baseline characteristics were similar between the subgroups, but International Staging System stage III disease was more common in high- vs standard-risk patients (41.9% vs 27.5%) as was Eastern Cooperative Oncology Group performance status 1/2 (85.5% vs 68.3%). Overall response was comparable between the subgroups (25.8% vs 24.6%, respectively; P=0.85), while time-to-event end points showed a trend of shorter duration in high-risk patients, including median duration of response (5.6 months (95% confidence interval (CI) 3.7-7.8) vs 8.3 months (95% CI 5.6-12.3)) and overall survival (9.3 (95% CI 6.5-13.0) vs 19.0 months (95% CI 15.4-NE); P=0.0003). Taken together, these findings demonstrate that single-agent carfilzomib is efficacious and has the potential to at least partially overcome the impact of high-risk cytogenetics in heavily pre-treated patients with MM." @default.
• W2068045978 created "2016-06-24" @default.
• W2068045978 creator A5010286156 @default.
• W2068045978 creator A5012403700 @default.
• W2068045978 creator A5023276777 @default.
• W2068045978 creator A5023752321 @default.
• W2068045978 creator A5023917993 @default.
• W2068045978 creator A5026151069 @default.
• W2068045978 creator A5027513506 @default.
• W2068045978 creator A5028046297 @default.
• W2068045978 creator A5029801761 @default.
• W2068045978 creator A5034791164 @default.
• W2068045978 creator A5038235561 @default.
• W2068045978 creator A5057911528 @default.
• W2068045978 creator A5065238694 @default.
• W2068045978 creator A5067291402 @default.
• W2068045978 creator A5069676334 @default.
• W2068045978 creator A5071804307 @default.
• W2068045978 creator A5077169512 @default.
• W2068045978 creator A5082082927 @default.
• W2068045978 creator A5082712392 @default.
• W2068045978 creator A5086115833 @default.
• W2068045978 creator A5087799564 @default.
• W2068045978 creator A5088497546 @default.
• W2068045978 date "2013-05-14" @default.
• W2068045978 modified "2023-10-12" @default.
• W2068045978 title "Treatment outcomes in patients with relapsed and refractory multiple myeloma and high-risk cytogenetics receiving single-agent carfilzomib in the PX-171-003-A1 study" @default.
• W2068045978 cites W1964227719 @default.
• W2068045978 cites W1968769311 @default.
• W2068045978 cites W1974656498 @default.
• W2068045978 cites W1977691688 @default.
• W2068045978 cites W1978377409 @default.
• W2068045978 cites W1995832783 @default.
• W2068045978 cites W2002605588 @default.
• W2068045978 cites W2007086602 @default.
• W2068045978 cites W2014073139 @default.
• W2068045978 cites W2015880063 @default.
• W2068045978 cites W2021785646 @default.
• W2068045978 cites W2029006246 @default.
• W2068045978 cites W2044436186 @default.
• W2068045978 cites W2051146376 @default.
• W2068045978 cites W2067697860 @default.
• W2068045978 cites W2075032656 @default.
• W2068045978 cites W2080218360 @default.
• W2068045978 cites W2082863510 @default.
• W2068045978 cites W2083365324 @default.
• W2068045978 cites W2087843841 @default.
• W2068045978 cites W2088540908 @default.
• W2068045978 cites W2089311432 @default.
• W2068045978 cites W2090310344 @default.
• W2068045978 cites W2091447224 @default.
• W2068045978 cites W2095255742 @default.
• W2068045978 cites W2096207943 @default.
• W2068045978 cites W2099334882 @default.
• W2068045978 cites W2126351771 @default.
• W2068045978 cites W2127575705 @default.
• W2068045978 cites W2128903704 @default.
• W2068045978 cites W2131837746 @default.
• W2068045978 cites W2142368474 @default.
• W2068045978 cites W2147644408 @default.
• W2068045978 cites W2151978071 @default.
• W2068045978 cites W2166508172 @default.
• W2068045978 cites W2170805515 @default.
• W2068045978 cites W2335581978 @default.
• W2068045978 cites W4211114373 @default.
• W2068045978 doi "https://doi.org/10.1038/leu.2013.152" @default.
• W2068045978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3865533" @default.
• W2068045978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23670297" @default.
• W2068045978 hasPublicationYear "2013" @default.
• W2068045978 type Work @default.
• W2068045978 sameAs 2068045978 @default.
• W2068045978 citedByCount "69" @default.
• W2068045978 countsByYear W20680459782013 @default.
• W2068045978 countsByYear W20680459782014 @default.
• W2068045978 countsByYear W20680459782015 @default.
• W2068045978 countsByYear W20680459782016 @default.
• W2068045978 countsByYear W20680459782017 @default.
• W2068045978 countsByYear W20680459782018 @default.
• W2068045978 countsByYear W20680459782019 @default.
• W2068045978 countsByYear W20680459782020 @default.
• W2068045978 countsByYear W20680459782021 @default.
• W2068045978 countsByYear W20680459782022 @default.
• W2068045978 crossrefType "journal-article" @default.
• W2068045978 hasAuthorship W2068045978A5010286156 @default.
• W2068045978 hasAuthorship W2068045978A5012403700 @default.
• W2068045978 hasAuthorship W2068045978A5023276777 @default.
• W2068045978 hasAuthorship W2068045978A5023752321 @default.
• W2068045978 hasAuthorship W2068045978A5023917993 @default.
• W2068045978 hasAuthorship W2068045978A5026151069 @default.
• W2068045978 hasAuthorship W2068045978A5027513506 @default.
• W2068045978 hasAuthorship W2068045978A5028046297 @default.
• W2068045978 hasAuthorship W2068045978A5029801761 @default.
• W2068045978 hasAuthorship W2068045978A5034791164 @default.
• W2068045978 hasAuthorship W2068045978A5038235561 @default.
• W2068045978 hasAuthorship W2068045978A5057911528 @default.
• W2068045978 hasAuthorship W2068045978A5065238694 @default.
• W2068045978 hasAuthorship W2068045978A5067291402 @default.
• W2068045978 hasAuthorship W2068045978A5069676334 @default.

• next