Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068049058> ?p ?o ?g. }
- W2068049058 endingPage "16" @default.
- W2068049058 startingPage "9" @default.
- W2068049058 abstract "In previous studies, fusion of peritoneal macrophages or blood monocytes with mouse melanoma cells produced hybrids with upregulated expression of the glycosyltransferase β1,6-N-acetylglucosaminyltransferase V (GnT-V) and its enzymatic product, β1,6-branched oligosaccharides. This correlated with marked increases in motility, metastatic potential and, surprisingly, melanin content. This study was designed to establish direct roles for β1,6-branched oligosaccharides in melanogenesis and motility. The levels of β1,6-branched oligosaccharides were lowered by transfecting β1,4-N-acetylglucosaminyltransferase III, a competitive inhibitor of GnT-V. β1,4-N-acetylglucosaminyltransferase III transfection virtually eliminated melanin production and markedly decreased chemotactic motility. This implied that the metastatic and melanogenic phenotypes in hybrids were each upregulated by β1,6-branched oligosaccharides. Although roles for β1,6-branched oligosaccharides in motility and metastasis have been reported previously, this is the first study to directly implicate these structures in melanogenesis. Although drawn from experimental models, the findings might explain the well known hypermelanotic regions of human cutaneous malignant melanoma as hypermelanotic cutaneous malignant melanoma cells are rich in β1,6-branched oligosaccharides. They might also explain why melanogenesis pathways differ between malignant and normal melanocytes as GnT-V is a myeloid-associated enzyme that is aberrantly expressed in melanoma cells but not in normal melanocytes." @default.
- W2068049058 created "2016-06-24" @default.
- W2068049058 creator A5051424752 @default.
- W2068049058 creator A5074038790 @default.
- W2068049058 date "2007-02-01" @default.
- W2068049058 modified "2023-10-18" @default.
- W2068049058 title "??1,6-branched oligosaccharides regulate melanin content and motility in macrophage???melanoma fusion hybrids" @default.
- W2068049058 cites W110933786 @default.
- W2068049058 cites W1489195678 @default.
- W2068049058 cites W1511386761 @default.
- W2068049058 cites W1569356536 @default.
- W2068049058 cites W1578874979 @default.
- W2068049058 cites W1645373081 @default.
- W2068049058 cites W1969586917 @default.
- W2068049058 cites W1970297269 @default.
- W2068049058 cites W1976631562 @default.
- W2068049058 cites W1980042217 @default.
- W2068049058 cites W1985176813 @default.
- W2068049058 cites W1986334743 @default.
- W2068049058 cites W2010790710 @default.
- W2068049058 cites W2013615451 @default.
- W2068049058 cites W2013727355 @default.
- W2068049058 cites W2016996190 @default.
- W2068049058 cites W2024101604 @default.
- W2068049058 cites W2026660298 @default.
- W2068049058 cites W2027702742 @default.
- W2068049058 cites W2029603201 @default.
- W2068049058 cites W2031461044 @default.
- W2068049058 cites W2033655539 @default.
- W2068049058 cites W2035685283 @default.
- W2068049058 cites W2036019256 @default.
- W2068049058 cites W2039378703 @default.
- W2068049058 cites W2042527484 @default.
- W2068049058 cites W2043581327 @default.
- W2068049058 cites W2045297055 @default.
- W2068049058 cites W2048065251 @default.
- W2068049058 cites W2050844328 @default.
- W2068049058 cites W2053654265 @default.
- W2068049058 cites W2055780937 @default.
- W2068049058 cites W2064413203 @default.
- W2068049058 cites W2067786533 @default.
- W2068049058 cites W2071213460 @default.
- W2068049058 cites W2073431306 @default.
- W2068049058 cites W2073440750 @default.
- W2068049058 cites W2076785665 @default.
- W2068049058 cites W2081461762 @default.
- W2068049058 cites W2083304463 @default.
- W2068049058 cites W2086996769 @default.
- W2068049058 cites W2087849476 @default.
- W2068049058 cites W2088277970 @default.
- W2068049058 cites W2090975642 @default.
- W2068049058 cites W2094049925 @default.
- W2068049058 cites W2094131378 @default.
- W2068049058 cites W2094247809 @default.
- W2068049058 cites W2096683453 @default.
- W2068049058 cites W2111251470 @default.
- W2068049058 cites W2119188243 @default.
- W2068049058 cites W2126353920 @default.
- W2068049058 cites W2141976152 @default.
- W2068049058 cites W2155884272 @default.
- W2068049058 cites W2156674768 @default.
- W2068049058 cites W2159318237 @default.
- W2068049058 cites W2171346238 @default.
- W2068049058 cites W2174494630 @default.
- W2068049058 cites W2209798740 @default.
- W2068049058 cites W2334220360 @default.
- W2068049058 cites W2416892795 @default.
- W2068049058 cites W2436001939 @default.
- W2068049058 cites W2949781359 @default.
- W2068049058 cites W4361865139 @default.
- W2068049058 cites W68824375 @default.
- W2068049058 doi "https://doi.org/10.1097/cmr.0b013e3280114f34" @default.
- W2068049058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17235237" @default.
- W2068049058 hasPublicationYear "2007" @default.
- W2068049058 type Work @default.
- W2068049058 sameAs 2068049058 @default.
- W2068049058 citedByCount "20" @default.
- W2068049058 countsByYear W20680490582012 @default.
- W2068049058 countsByYear W20680490582013 @default.
- W2068049058 countsByYear W20680490582014 @default.
- W2068049058 countsByYear W20680490582016 @default.
- W2068049058 countsByYear W20680490582017 @default.
- W2068049058 crossrefType "journal-article" @default.
- W2068049058 hasAuthorship W2068049058A5051424752 @default.
- W2068049058 hasAuthorship W2068049058A5074038790 @default.
- W2068049058 hasConcept C104317684 @default.
- W2068049058 hasConcept C107538193 @default.
- W2068049058 hasConcept C127561419 @default.
- W2068049058 hasConcept C127716648 @default.
- W2068049058 hasConcept C170493617 @default.
- W2068049058 hasConcept C181199279 @default.
- W2068049058 hasConcept C185592680 @default.
- W2068049058 hasConcept C2777658100 @default.
- W2068049058 hasConcept C502942594 @default.
- W2068049058 hasConcept C54009773 @default.
- W2068049058 hasConcept C54166955 @default.
- W2068049058 hasConcept C55493867 @default.
- W2068049058 hasConcept C58207958 @default.