FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068049396> ?p ?o ?g. }

• W2068049396 endingPage "1753" @default.
• W2068049396 startingPage "1744" @default.
• W2068049396 abstract "Abstract Microglia are the resident immune cells in the brain. Under normal conditions, resting ramified microglia constantly extend and retract fine processes while performing immunological surveillance. In ischemia, microglia become activated as demonstrated by morphological changes during deramification leading to transformation from ramified to amoeboid form. In vivo two‐photon microscopy of enhanced green fluorescent protein (EGFP)‐expressing microglia in mouse neocortex was used to examine microglial dynamics during the early periods of focal and global ischemia. A penumbra‐like “area‐at‐risk” surrounded by a square‐shaped area of severely hypoperfused tissue was created by laser‐induced photothrombosis. The dynamics of microglial processes in the area‐at‐risk was strongly correlated with capillary blood flow (BF) measured within 10 μm of microglial somata. Changes in BF around distal microglial processes (>30 μm from somata) had no effect on microglial dynamics. A severe reduction of capillary BF near somata by 84% ± 6% resulted in initiation of microglial deramification, suggesting activation. A moderate decrease in BF near somata by 22% ± 5% or increase by 87% ± 10%, reflecting a redistribution of capillary BF, had no effect on microglial morphology. Complete BF loss during cardiac arrest (CA) or transient bilateral common carotid artery occlusion (BCCAO) entirely stalled all microglial processes without structural changes. Reperfusion after BCCAO induced recovery of microglial dynamics to preocclusion values. These findings suggest that during ischemia, the severe drop in BF around microglial somata coincides with morphological activation. However, this activation requires some residual BF, because complete perfusion loss (as during BCCAO and CA) did not support microglial deramification. © 2011 Wiley‐Liss, Inc." @default.
• W2068049396 created "2016-06-24" @default.
• W2068049396 creator A5037938897 @default.
• W2068049396 creator A5085979969 @default.
• W2068049396 creator A5086272998 @default.
• W2068049396 creator A5090393375 @default.
• W2068049396 date "2011-07-28" @default.
• W2068049396 modified "2023-10-15" @default.
• W2068049396 title "Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions" @default.
• W2068049396 cites W1551550807 @default.
• W2068049396 cites W1931754955 @default.
• W2068049396 cites W1964041350 @default.
• W2068049396 cites W1971668430 @default.
• W2068049396 cites W1972534236 @default.
• W2068049396 cites W1975239722 @default.
• W2068049396 cites W1977794959 @default.
• W2068049396 cites W1984131513 @default.
• W2068049396 cites W1996057550 @default.
• W2068049396 cites W2002663490 @default.
• W2068049396 cites W2003674452 @default.
• W2068049396 cites W2004492484 @default.
• W2068049396 cites W2006077073 @default.
• W2068049396 cites W2008613303 @default.
• W2068049396 cites W2014023829 @default.
• W2068049396 cites W2022743575 @default.
• W2068049396 cites W2029481004 @default.
• W2068049396 cites W2031809301 @default.
• W2068049396 cites W2039862570 @default.
• W2068049396 cites W2040572204 @default.
• W2068049396 cites W2041832019 @default.
• W2068049396 cites W2046257967 @default.
• W2068049396 cites W2049135473 @default.
• W2068049396 cites W2049308987 @default.
• W2068049396 cites W2053019147 @default.
• W2068049396 cites W2057332354 @default.
• W2068049396 cites W2062216455 @default.
• W2068049396 cites W2066943555 @default.
• W2068049396 cites W2073402789 @default.
• W2068049396 cites W2085164809 @default.
• W2068049396 cites W2085477318 @default.
• W2068049396 cites W2090189531 @default.
• W2068049396 cites W2094660330 @default.
• W2068049396 cites W2098237962 @default.
• W2068049396 cites W2109759840 @default.
• W2068049396 cites W2111433735 @default.
• W2068049396 cites W2113107925 @default.
• W2068049396 cites W2122828560 @default.
• W2068049396 cites W2126316813 @default.
• W2068049396 cites W2126496496 @default.
• W2068049396 cites W2127810309 @default.
• W2068049396 cites W2129762934 @default.
• W2068049396 cites W2131686384 @default.
• W2068049396 cites W2132381902 @default.
• W2068049396 cites W2137927688 @default.
• W2068049396 cites W2144918294 @default.
• W2068049396 cites W2154840243 @default.
• W2068049396 cites W2161057248 @default.
• W2068049396 cites W2169118010 @default.
• W2068049396 doi "https://doi.org/10.1002/glia.21220" @default.
• W2068049396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174346" @default.
• W2068049396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21800362" @default.
• W2068049396 hasPublicationYear "2011" @default.
• W2068049396 type Work @default.
• W2068049396 sameAs 2068049396 @default.
• W2068049396 citedByCount "78" @default.
• W2068049396 countsByYear W20680493962012 @default.
• W2068049396 countsByYear W20680493962013 @default.
• W2068049396 countsByYear W20680493962014 @default.
• W2068049396 countsByYear W20680493962015 @default.
• W2068049396 countsByYear W20680493962016 @default.
• W2068049396 countsByYear W20680493962017 @default.
• W2068049396 countsByYear W20680493962018 @default.
• W2068049396 countsByYear W20680493962019 @default.
• W2068049396 countsByYear W20680493962020 @default.
• W2068049396 countsByYear W20680493962021 @default.
• W2068049396 countsByYear W20680493962022 @default.
• W2068049396 countsByYear W20680493962023 @default.
• W2068049396 crossrefType "journal-article" @default.
• W2068049396 hasAuthorship W2068049396A5037938897 @default.
• W2068049396 hasAuthorship W2068049396A5085979969 @default.
• W2068049396 hasAuthorship W2068049396A5086272998 @default.
• W2068049396 hasAuthorship W2068049396A5090393375 @default.
• W2068049396 hasBestOaLocation W20680493962 @default.
• W2068049396 hasConcept C12554922 @default.
• W2068049396 hasConcept C126322002 @default.
• W2068049396 hasConcept C142724271 @default.
• W2068049396 hasConcept C146957229 @default.
• W2068049396 hasConcept C150903083 @default.
• W2068049396 hasConcept C169760540 @default.
• W2068049396 hasConcept C203014093 @default.
• W2068049396 hasConcept C207001950 @default.
• W2068049396 hasConcept C2776914184 @default.
• W2068049396 hasConcept C2779830541 @default.
• W2068049396 hasConcept C2780577055 @default.
• W2068049396 hasConcept C541997718 @default.
• W2068049396 hasConcept C71924100 @default.
• W2068049396 hasConcept C86803240 @default.
• W2068049396 hasConceptScore W2068049396C12554922 @default.

• next