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- W2068049688 abstract "Ultraviolet (UV) radiation has been widely used in medicine, and in recent years there has been a growing interest in narrow-band UVB therapies, especially those employing pulses of the 308-nm line of XeCl excimer lasers. Comparative studies in several skin pathologies showed that narrow-band UVB was more effective than classical broad-band UVB radiation. Simultaneously, UVB is carcinogenic and there is a need for data to establish the risk associated with phototherapies involving irradiations of human skin with different doses of narrow- and broad-band UVA and/or UVB radiation. Relevant data are sparse predominantly due to a lack of suitable model systems for study of this phenomenon. Our comparative study of human and porcine skin responses to pulses of narrow-band UVB radiation demonstrated that for doses ranging from 5 to 10,000 mJ/cm(2) both skin types have similar susceptibility to UVB-induced breaking of nuclear DNA, indicating that pig skin might serve as good model for studies of sensitivity of human skin to UVB radiation." @default.
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- W2068049688 date "2009-06-30" @default.
- W2068049688 modified "2023-10-18" @default.
- W2068049688 title "Porcine Skin as a Model System for Studies of Adverse Effects of Narrow-Band UVB Pulses on Human Skin" @default.
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- W2068049688 doi "https://doi.org/10.1080/15287390902800363" @default.
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