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- W2068058863 abstract "The effect of prolactin (PRL) treatment on estrogen production by rat granulosa cells was investigated in vitro. Immature, hypophysectomized, DES-treated rats were injected for 2 days with FSH to induce aromatase enzymes and receptors for PRL and LH. After FSH priming, the granulosa cells were cultured for 4 days in serum-free medium containing 10−7 M androstenedione and purified FSH, LH and/or PRL. A dose-related inhibition of estrogen production from control cells was observed following PRL treatment in which 1 μg/ml of PRL inhibited estrogen formation by > 90%. In these same cultures, PRL caused a dose-related increase in progesterone and 20α-dihydroprogesterone secretion. Treatment with purified FSH or LH stimulated estrogen synthesis by 3–10-fold. Concomitant treatment with PRL suppressed the FSH- and LH-induced increases in estrogen production in a dose-dependent manner; 1 μg/ml PRL suppressed estrogen production by > 80% during days 2–4 of culture. In these same cultures, PRL did not alter the stimulatory effects of FSH and LH on progesterone and 20α-dihydroprogesterone production. These experiments demonstrate that PRL acts directly on rat granulosa cells in vitro to suppress basal and gonadotropin-induced increases in estrogen production." @default.
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- W2068058863 date "1980-11-01" @default.
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- W2068058863 title "Prolactin inhibition of estrogen production by cultured rat granulosa cells" @default.
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- W2068058863 doi "https://doi.org/10.1016/0303-7207(80)90077-5" @default.
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