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- W2068060182 abstract "Abstract A multicenter, randomized, double-blind, placebo-controlled, cross-over clinical study was performed to determine the effects of systemic flunisolide on the symptoms of 20 children with chronic severe atopic dermatitis. The study lasted 5 weeks. Ten of the 20 patients received flunisolide for 2 weeks followed by placebo for 2 weeks; the other 10 patients received placebo for 2 weeks and then flunisolide for 2 weeks. A 1-week washout period separated the administration of each treatment. Clinical symptoms were assessed at baseline (week 0) and weeks 2, 3, and 5. Total clinical severity scores indicated a significant improvement of symptoms in patients after 2 weeks of flunisolide treatment, compared with the placebo group. After treatment with flunisolide, no worsening of symptoms or relapse occurred. In the placebo group, no significant reduction in clinical scores was observed and, moreover, three patients demonstrated worsening of symptoms during the washout period that followed the placebo treatment. However, this group had a prompt reduction in clinical scores after administration of flunisolide. No side effects were observed during the study. The data suggest that, in children with severe atopic dermatitis, short courses of flunisolide can provide relief while awaiting response to other agents or during severe exacerbations of symptoms. Thus flunisolide is an alternative to traditional oral steroids and has no noticeable side effects." @default.
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- W2068060182 date "1995-07-01" @default.
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- W2068060182 title "A randomized, double-blind, placebo-controlled, crossover trial of systemic flunisolide in the treatment of children with severe atopic dermatitis" @default.
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- W2068060182 doi "https://doi.org/10.1016/0011-393x(95)85143-7" @default.
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