FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068069968> ?p ?o ?g. }

• W2068069968 endingPage "204" @default.
• W2068069968 startingPage "197" @default.
• W2068069968 abstract "The authors describe a new approach to glioblastoma multiforme (GBM) therapy using therapeutic stem cells encapsulated in biodegradable synthetic extracellular matrix in mouse models of human GBM resection. Therapeutically engineered stem cells have shown promise for glioblastoma multiforme (GBM) therapy; however, key preclinical studies are urgently needed for their clinical translation. In this study, we investigated a new approach to GBM treatment using therapeutic stem cells encapsulated in biodegradable, synthetic extracellular matrix (sECM) in mouse models of human GBM resection. Using multimodal imaging, we first showed quantitative surgical debulking of human GBM tumors in mice, which resulted in increased survival. Next, sECM encapsulation of engineered stem cells increased their retention in the tumor resection cavity, permitted tumor-selective migration and release of diagnostic and therapeutic proteins in vivo. Simulating the clinical scenario of GBM treatment, the release of tumor-selective S-TRAIL (secretable tumor necrosis factor apoptosis inducing ligand) from sECM-encapsulated stem cells in the resection cavity eradicated residual tumor cells by inducing caspase-mediated apoptosis, delayed tumor regrowth and significantly increased survival of mice. This study demonstrates the efficacy of encapsulated therapeutic stem cells in mouse models of GBM resection and may have implications for developing effective therapies for GBM." @default.
• W2068069968 created "2016-06-24" @default.
• W2068069968 creator A5034567480 @default.
• W2068069968 creator A5049584767 @default.
• W2068069968 creator A5054850007 @default.
• W2068069968 creator A5086220759 @default.
• W2068069968 date "2011-12-25" @default.
• W2068069968 modified "2023-10-16" @default.
• W2068069968 title "Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas" @default.
• W2068069968 cites W1738003656 @default.
• W2068069968 cites W1966369003 @default.
• W2068069968 cites W1966542708 @default.
• W2068069968 cites W1971886578 @default.
• W2068069968 cites W1975306522 @default.
• W2068069968 cites W1975585599 @default.
• W2068069968 cites W1984423771 @default.
• W2068069968 cites W1995027228 @default.
• W2068069968 cites W2000534793 @default.
• W2068069968 cites W2018992636 @default.
• W2068069968 cites W2020294006 @default.
• W2068069968 cites W2025128734 @default.
• W2068069968 cites W2026491130 @default.
• W2068069968 cites W2030338665 @default.
• W2068069968 cites W2032342631 @default.
• W2068069968 cites W2033013430 @default.
• W2068069968 cites W2036044314 @default.
• W2068069968 cites W2040222222 @default.
• W2068069968 cites W2049970280 @default.
• W2068069968 cites W2052225969 @default.
• W2068069968 cites W2055009621 @default.
• W2068069968 cites W2055905844 @default.
• W2068069968 cites W2062008885 @default.
• W2068069968 cites W2072365921 @default.
• W2068069968 cites W2075011928 @default.
• W2068069968 cites W2080694397 @default.
• W2068069968 cites W2084936473 @default.
• W2068069968 cites W2085722674 @default.
• W2068069968 cites W2086120407 @default.
• W2068069968 cites W2088335906 @default.
• W2068069968 cites W2089735370 @default.
• W2068069968 cites W2092472464 @default.
• W2068069968 cites W2093518077 @default.
• W2068069968 cites W2101891613 @default.
• W2068069968 cites W2110347501 @default.
• W2068069968 cites W2110803302 @default.
• W2068069968 cites W2115625696 @default.
• W2068069968 cites W2123450039 @default.
• W2068069968 cites W2127846410 @default.
• W2068069968 cites W2128756334 @default.
• W2068069968 cites W2130133905 @default.
• W2068069968 cites W2141433020 @default.
• W2068069968 cites W2141815918 @default.
• W2068069968 cites W2143308874 @default.
• W2068069968 cites W2143554919 @default.
• W2068069968 cites W2147464758 @default.
• W2068069968 cites W2148258332 @default.
• W2068069968 cites W2165123465 @default.
• W2068069968 cites W2168849090 @default.
• W2068069968 doi "https://doi.org/10.1038/nn.3019" @default.
• W2068069968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3601490" @default.
• W2068069968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22197831" @default.
• W2068069968 hasPublicationYear "2011" @default.
• W2068069968 type Work @default.
• W2068069968 sameAs 2068069968 @default.
• W2068069968 citedByCount "190" @default.
• W2068069968 countsByYear W20680699682012 @default.
• W2068069968 countsByYear W20680699682013 @default.
• W2068069968 countsByYear W20680699682014 @default.
• W2068069968 countsByYear W20680699682015 @default.
• W2068069968 countsByYear W20680699682016 @default.
• W2068069968 countsByYear W20680699682017 @default.
• W2068069968 countsByYear W20680699682018 @default.
• W2068069968 countsByYear W20680699682019 @default.
• W2068069968 countsByYear W20680699682020 @default.
• W2068069968 countsByYear W20680699682021 @default.
• W2068069968 countsByYear W20680699682022 @default.
• W2068069968 countsByYear W20680699682023 @default.
• W2068069968 crossrefType "journal-article" @default.
• W2068069968 hasAuthorship W2068069968A5034567480 @default.
• W2068069968 hasAuthorship W2068069968A5049584767 @default.
• W2068069968 hasAuthorship W2068069968A5054850007 @default.
• W2068069968 hasAuthorship W2068069968A5086220759 @default.
• W2068069968 hasBestOaLocation W20680699682 @default.
• W2068069968 hasConcept C121608353 @default.
• W2068069968 hasConcept C126322002 @default.
• W2068069968 hasConcept C128473837 @default.
• W2068069968 hasConcept C142724271 @default.
• W2068069968 hasConcept C150903083 @default.
• W2068069968 hasConcept C189165786 @default.
• W2068069968 hasConcept C190283241 @default.
• W2068069968 hasConcept C207001950 @default.
• W2068069968 hasConcept C2776194525 @default.
• W2068069968 hasConcept C2780427987 @default.
• W2068069968 hasConcept C2781100745 @default.
• W2068069968 hasConcept C28328180 @default.
• W2068069968 hasConcept C502942594 @default.
• W2068069968 hasConcept C55493867 @default.
• W2068069968 hasConcept C71924100 @default.

• next