FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068077324> ?p ?o ?g. }

• W2068077324 endingPage "3377" @default.
• W2068077324 startingPage "3367" @default.
• W2068077324 abstract "The ATR (ATM and Rad3-related) kinase is essential to maintain genomic integrity. ATR is recruited to DNA lesions in part through its association with ATR-interacting protein (ATRIP), which in turn interacts with the single-stranded DNA binding protein RPA (replication protein A). In this study, a conserved checkpoint protein recruitment domain (CRD) in ATRIP orthologs was identified by biochemical mapping of the RPA binding site in combination with nuclear magnetic resonance, mutagenesis, and computational modeling. Mutations in the CRD of the Saccharomyces cerevisiae ATRIP ortholog Ddc2 disrupt the Ddc2-RPA interaction, prevent proper localization of Ddc2 to DNA breaks, sensitize yeast to DNA-damaging agents, and partially compromise checkpoint signaling. These data demonstrate that the CRD is critical for localization and optimal DNA damage responses. However, the stimulation of ATR kinase activity by binding of topoisomerase binding protein 1 (TopBP1) to ATRIP-ATR can occur independently of the interaction of ATRIP with RPA. Our results support the idea of a multistep model for ATR activation that requires separable localization and activation functions of ATRIP." @default.
• W2068077324 created "2016-06-24" @default.
• W2068077324 creator A5003392314 @default.
• W2068077324 creator A5004224732 @default.
• W2068077324 creator A5015725887 @default.
• W2068077324 creator A5037162298 @default.
• W2068077324 creator A5070707099 @default.
• W2068077324 creator A5079267142 @default.
• W2068077324 date "2007-05-01" @default.
• W2068077324 modified "2023-10-11" @default.
• W2068077324 title "Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins" @default.
• W2068077324 cites W1484495480 @default.
• W2068077324 cites W1504970629 @default.
• W2068077324 cites W1563743635 @default.
• W2068077324 cites W1840165714 @default.
• W2068077324 cites W1961560739 @default.
• W2068077324 cites W1965659139 @default.
• W2068077324 cites W1968552183 @default.
• W2068077324 cites W1970772221 @default.
• W2068077324 cites W1986121915 @default.
• W2068077324 cites W1992876574 @default.
• W2068077324 cites W1994224457 @default.
• W2068077324 cites W1999554125 @default.
• W2068077324 cites W2003205927 @default.
• W2068077324 cites W2013947447 @default.
• W2068077324 cites W2014084740 @default.
• W2068077324 cites W2016888788 @default.
• W2068077324 cites W2017289276 @default.
• W2068077324 cites W2022327201 @default.
• W2068077324 cites W2029369774 @default.
• W2068077324 cites W2031292590 @default.
• W2068077324 cites W2034033535 @default.
• W2068077324 cites W2043895957 @default.
• W2068077324 cites W2047936759 @default.
• W2068077324 cites W2051402439 @default.
• W2068077324 cites W2054813812 @default.
• W2068077324 cites W2055604308 @default.
• W2068077324 cites W2060355419 @default.
• W2068077324 cites W2061060103 @default.
• W2068077324 cites W2065588235 @default.
• W2068077324 cites W2067022597 @default.
• W2068077324 cites W2079156670 @default.
• W2068077324 cites W2081171606 @default.
• W2068077324 cites W2084138017 @default.
• W2068077324 cites W2094961621 @default.
• W2068077324 cites W2096219875 @default.
• W2068077324 cites W2099024365 @default.
• W2068077324 cites W2101942126 @default.
• W2068077324 cites W2101988823 @default.
• W2068077324 cites W2107130407 @default.
• W2068077324 cites W2117372086 @default.
• W2068077324 cites W2119386919 @default.
• W2068077324 cites W2125299927 @default.
• W2068077324 cites W2134049133 @default.
• W2068077324 cites W2134327149 @default.
• W2068077324 cites W2136145320 @default.
• W2068077324 cites W2152441728 @default.
• W2068077324 cites W2154051092 @default.
• W2068077324 cites W2155071772 @default.
• W2068077324 cites W2158307923 @default.
• W2068077324 cites W2161699458 @default.
• W2068077324 cites W2170519022 @default.
• W2068077324 cites W2171041530 @default.
• W2068077324 doi "https://doi.org/10.1128/mcb.02238-06" @default.
• W2068077324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1899971" @default.
• W2068077324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17339343" @default.
• W2068077324 hasPublicationYear "2007" @default.
• W2068077324 type Work @default.
• W2068077324 sameAs 2068077324 @default.
• W2068077324 citedByCount "125" @default.
• W2068077324 countsByYear W20680773242012 @default.
• W2068077324 countsByYear W20680773242013 @default.
• W2068077324 countsByYear W20680773242014 @default.
• W2068077324 countsByYear W20680773242015 @default.
• W2068077324 countsByYear W20680773242016 @default.
• W2068077324 countsByYear W20680773242017 @default.
• W2068077324 countsByYear W20680773242018 @default.
• W2068077324 countsByYear W20680773242019 @default.
• W2068077324 countsByYear W20680773242020 @default.
• W2068077324 countsByYear W20680773242021 @default.
• W2068077324 countsByYear W20680773242022 @default.
• W2068077324 countsByYear W20680773242023 @default.
• W2068077324 crossrefType "journal-article" @default.
• W2068077324 hasAuthorship W2068077324A5003392314 @default.
• W2068077324 hasAuthorship W2068077324A5004224732 @default.
• W2068077324 hasAuthorship W2068077324A5015725887 @default.
• W2068077324 hasAuthorship W2068077324A5037162298 @default.
• W2068077324 hasAuthorship W2068077324A5070707099 @default.
• W2068077324 hasAuthorship W2068077324A5079267142 @default.
• W2068077324 hasBestOaLocation W20680773242 @default.
• W2068077324 hasConcept C104317684 @default.
• W2068077324 hasConcept C113271649 @default.
• W2068077324 hasConcept C143425029 @default.
• W2068077324 hasConcept C153911025 @default.
• W2068077324 hasConcept C2777576037 @default.
• W2068077324 hasConcept C502942594 @default.
• W2068077324 hasConcept C54355233 @default.
• W2068077324 hasConcept C552990157 @default.

• next