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- W2068078051 abstract "The lethality of morphine (37.5, 75, and 150 mg/kg) and tripelennamine (10, 20, 40 and 60 mg/kg), given alone and in combination, was evaluated in mice housed in groups of 16. When given alone, neither drug produced death at any dose. Combining the drugs produced supra-additive effects: some deaths occurred at all combination doses. The lethality of pentazocine (20, 40 and 80 mg/kg) and diphenhydramine (20, 40 and 80 mg/kg), given alone and in combination, also was evaluated. Neither drug alone produced death at any dose. Supra-additive effects were observed when the drugs were combined. These results are similar to earlier findings concerning the lethality of combinations of pentazocine and triplennamine." @default.
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- W2068078051 date "1985-02-01" @default.
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- W2068078051 title "Lethality of opioid and antihistaminic combinations in mice" @default.
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- W2068078051 doi "https://doi.org/10.1016/0091-3057(85)90399-5" @default.
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