FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068082172> ?p ?o ?g. }

• W2068082172 endingPage "394" @default.
• W2068082172 startingPage "390" @default.
• W2068082172 abstract "The ‘thrifty phenotype’ hypothesis proposes that the fetus adapts to an adverse intrauterine milieu by optimizing the use of a reduced nutrient supply to ensure survival. However, favoring the development of some organs over that of others leads to persistent alterations in the growth and function of developing tissues. Although this concept has been somewhat controversial, recent epidemiological, clinical and animal studies provide support for the developmental origins of disease hypothesis. Underlying mechanisms include reprogramming of the hypothalamic–pituitary–adrenal axis, islet development and insulin-signaling pathways. Emerging data indicates that epigenetic regulation of gene expression might also play a crucial role in the pathogenesis of type 2 diabetes in individuals who are growth retarded at birth. The ‘thrifty phenotype’ hypothesis proposes that the fetus adapts to an adverse intrauterine milieu by optimizing the use of a reduced nutrient supply to ensure survival. However, favoring the development of some organs over that of others leads to persistent alterations in the growth and function of developing tissues. Although this concept has been somewhat controversial, recent epidemiological, clinical and animal studies provide support for the developmental origins of disease hypothesis. Underlying mechanisms include reprogramming of the hypothalamic–pituitary–adrenal axis, islet development and insulin-signaling pathways. Emerging data indicates that epigenetic regulation of gene expression might also play a crucial role in the pathogenesis of type 2 diabetes in individuals who are growth retarded at birth." @default.
• W2068082172 created "2016-06-24" @default.
• W2068082172 creator A5077604020 @default.
• W2068082172 date "2005-10-01" @default.
• W2068082172 modified "2023-09-23" @default.
• W2068082172 title "Developmental origins of adult metabolic disease: concepts and controversies" @default.
• W2068082172 cites W1531334610 @default.
• W2068082172 cites W1967832563 @default.
• W2068082172 cites W1972302024 @default.
• W2068082172 cites W1974959407 @default.
• W2068082172 cites W1975535652 @default.
• W2068082172 cites W1977329103 @default.
• W2068082172 cites W1984119010 @default.
• W2068082172 cites W1986965538 @default.
• W2068082172 cites W1988168615 @default.
• W2068082172 cites W1993932990 @default.
• W2068082172 cites W1997640175 @default.
• W2068082172 cites W2005484671 @default.
• W2068082172 cites W2009265841 @default.
• W2068082172 cites W2009936399 @default.
• W2068082172 cites W2010290591 @default.
• W2068082172 cites W2011576149 @default.
• W2068082172 cites W2014135861 @default.
• W2068082172 cites W2016562893 @default.
• W2068082172 cites W2017507345 @default.
• W2068082172 cites W2018181621 @default.
• W2068082172 cites W2025170466 @default.
• W2068082172 cites W2048056915 @default.
• W2068082172 cites W2051906308 @default.
• W2068082172 cites W2055042591 @default.
• W2068082172 cites W2058724069 @default.
• W2068082172 cites W2068927260 @default.
• W2068082172 cites W2093311675 @default.
• W2068082172 cites W2096534598 @default.
• W2068082172 cites W2097200084 @default.
• W2068082172 cites W2103246764 @default.
• W2068082172 cites W2104210194 @default.
• W2068082172 cites W2104479115 @default.
• W2068082172 cites W2110952210 @default.
• W2068082172 cites W2116209576 @default.
• W2068082172 cites W2116608031 @default.
• W2068082172 cites W2121707058 @default.
• W2068082172 cites W2133023141 @default.
• W2068082172 cites W2139379883 @default.
• W2068082172 cites W2141089991 @default.
• W2068082172 cites W2150065866 @default.
• W2068082172 cites W2151172803 @default.
• W2068082172 cites W2156524955 @default.
• W2068082172 cites W2157655909 @default.
• W2068082172 cites W2158068037 @default.
• W2068082172 cites W2160827694 @default.
• W2068082172 cites W2164404896 @default.
• W2068082172 cites W2167864556 @default.
• W2068082172 cites W2169300564 @default.
• W2068082172 cites W2170505333 @default.
• W2068082172 cites W2172253734 @default.
• W2068082172 cites W2232189333 @default.
• W2068082172 cites W4235629919 @default.
• W2068082172 cites W4239017375 @default.
• W2068082172 cites W4251619770 @default.
• W2068082172 doi "https://doi.org/10.1016/j.tem.2005.08.004" @default.
• W2068082172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16118054" @default.
• W2068082172 hasPublicationYear "2005" @default.
• W2068082172 type Work @default.
• W2068082172 sameAs 2068082172 @default.
• W2068082172 citedByCount "112" @default.
• W2068082172 countsByYear W20680821722012 @default.
• W2068082172 countsByYear W20680821722013 @default.
• W2068082172 countsByYear W20680821722014 @default.
• W2068082172 countsByYear W20680821722015 @default.
• W2068082172 countsByYear W20680821722016 @default.
• W2068082172 countsByYear W20680821722017 @default.
• W2068082172 countsByYear W20680821722018 @default.
• W2068082172 countsByYear W20680821722019 @default.
• W2068082172 countsByYear W20680821722020 @default.
• W2068082172 countsByYear W20680821722021 @default.
• W2068082172 countsByYear W20680821722022 @default.
• W2068082172 countsByYear W20680821722023 @default.
• W2068082172 crossrefType "journal-article" @default.
• W2068082172 hasAuthorship W2068082172A5077604020 @default.
• W2068082172 hasConcept C104317684 @default.
• W2068082172 hasConcept C126322002 @default.
• W2068082172 hasConcept C127716648 @default.
• W2068082172 hasConcept C134018914 @default.
• W2068082172 hasConcept C150194340 @default.
• W2068082172 hasConcept C179463898 @default.
• W2068082172 hasConcept C190727270 @default.
• W2068082172 hasConcept C2779134260 @default.
• W2068082172 hasConcept C41091548 @default.
• W2068082172 hasConcept C54355233 @default.
• W2068082172 hasConcept C60644358 @default.
• W2068082172 hasConcept C71924100 @default.
• W2068082172 hasConcept C77255625 @default.
• W2068082172 hasConcept C86803240 @default.
• W2068082172 hasConceptScore W2068082172C104317684 @default.
• W2068082172 hasConceptScore W2068082172C126322002 @default.
• W2068082172 hasConceptScore W2068082172C127716648 @default.
• W2068082172 hasConceptScore W2068082172C134018914 @default.

• next