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• W2068085644 abstract "Recent work has demonstrated that charged gold nanoparticles (AuNPs) protected by an amphiphilic organic monolayer can spontaneously insert into the core of lipid bilayers to minimize the exposure of hydrophobic surface area to water. However, the kinetic pathway to reach the thermodynamically stable transmembrane configuration is unknown. Here, we use unbiased atomistic simulations to show the pathway by which AuNPs spontaneously insert into bilayers and confirm the results experimentally on supported lipid bilayers. The critical step during this process is hydrophobic–hydrophobic contact between the core of the bilayer and the monolayer of the AuNP that requires the stochastic protrusion of an aliphatic lipid tail into solution. This last phenomenon is enhanced in the presence of high bilayer curvature and closely resembles the putative pre-stalk transition state for vesicle fusion. To the best of our knowledge, this work provides the first demonstration of vesicle fusion-like behaviour in an amphiphilic nanoparticle system. Gold nanoparticles coated with amphiphilic ligands can spontaneously insert into lipid bilayers, reducing hydrophobic interactions. Here, the authors show the key step in this process is similar to vesicle fusion: lipid tails from the bilayer protrude into water before encountering the nanoparticle." @default.
• W2068085644 created "2016-06-24" @default.
• W2068085644 creator A5006707355 @default.
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• W2068085644 date "2014-07-21" @default.
• W2068085644 modified "2023-10-18" @default.
• W2068085644 title "Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes" @default.
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• W2068085644 doi "https://doi.org/10.1038/ncomms5482" @default.
• W2068085644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25042518" @default.
• W2068085644 hasPublicationYear "2014" @default.
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