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• W2068085882 abstract "This study evaluates the functional activity of the mouse sweat glands in response to cholinergic agonists and antagonists using the silicone imprint technique. In intact mice the response to acetylcholine, methacholine and pilocarpine did not differ significantly from control saline injection, indicating that immobilization induces high levels of sweating, masking the effects of cholinergic stimulation. Plantar emotional sweating was completely abolished by local anesthesia at the ankle. Under these conditions, administration of acetylcholine only provoked detectable sweating when injected locally into the sole skin. Methacholine activated an increasing number of sweat glands in a dose-dependent manner between 0.5 and 10 mg/kg; the response was maximal after 5-10 min of administration and decreased subsequently. With pilocarpine the maximum number of reactive sweat glands was observed at a dose of 2.5 mg/kg. The response was stable for 45 min with doses 2.5 and 5 mg/kg, but decreased exponentially with higher doses. The subtype of sweat gland muscarinic receptor was characterized by determining the inhibitory effect of different cholinergic antagonists on pilocarpine response. Atropine and 4-DAMP were equally potent inhibitors, showing a dose-related effect from 0.05 mg/kg. Pirenzepine only showed inhibitory effects with doses 10-times higher, whereas gallamine and hexamethonium did not induce inhibition at any of the doses tested. These findings suggest that the mouse eccrine sweat gland muscarinic receptors are predominantly M3." @default.
• W2068085882 created "2016-06-24" @default.
• W2068085882 creator A5028187141 @default.
• W2068085882 creator A5069990332 @default.
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• W2068085882 date "1995-10-01" @default.
• W2068085882 modified "2023-10-16" @default.
• W2068085882 title "Functional sudomotor responses to cholinergic agonists and antagonists in the mouse" @default.
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• W2068085882 doi "https://doi.org/10.1016/0165-1838(95)00033-t" @default.
• W2068085882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8690842" @default.
• W2068085882 hasPublicationYear "1995" @default.
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