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- W2068086750 endingPage "149" @default.
- W2068086750 startingPage "135" @default.
- W2068086750 abstract "T cell independent antigens do not require T cell help to induce an immune response, and are characterized by a lack of immunologic memory. These antigens can be divided into two classes, TI-1 or TI-2. TI-1 antigens, such as bacterial lipopolysaccharide, are potent B-cell mitogens, capable of non-specific, polyclonal activation of B cells. In contrast, TI-2 antigens can only activate mature B cells and consist of highly repetitive structures, such as capsular polysaccharides (CPS) from bacteria. Many vaccines currently in use consist of purified capsular polysaccharides from pathogenic bacteria such as Streptococcus pneumoniae and Neisseria meningitidis. These vaccines are efficacious in immune-competent adults, however, due to their TI-2 nature, are not effective in children <2 years of age. Converting polysaccharides into T cell dependent (TD) antigens, allows children, <2, to produce an effective immune response. This review focuses on various strategies used to convert the immune response to polysaccharide antigens from TI-2 to a TD response. Conjugate vaccines, anti-idiotypic antibodies, phage display library technology and DNA vaccines are discussed." @default.
- W2068086750 created "2016-06-24" @default.
- W2068086750 creator A5032094154 @default.
- W2068086750 creator A5082857268 @default.
- W2068086750 date "2001-11-01" @default.
- W2068086750 modified "2023-09-23" @default.
- W2068086750 title "Novel vaccine strategies to T-independent antigens" @default.
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