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• W2068092241 abstract "Chiral PCB congeners are major components of PCB mixtures and undergo enantioselective biotransformation to hydroxylated (OH-)PCBs by cytochrome P450 enzymes. While it is known that biotransformation results in an enantiomeric enrichment of the parent PCB, it is currently unknown if OH-PCBs are formed enantioselectively. The present study screened seven commercial capillary gas chromatography columns containing modified β- or γ-cyclodextrins for their potential to separate the atropisomers of methylated derivatives of OH-PCB. The atropisomers of 3-, 4- and 5-methoxy derivatives were at least partially separated on one or more columns. A subsequent biotransformation study was performed with rat liver microsomes to assess if hydroxylated metabolites are formed enantioselectively from PCBs 91, 95, 132, and 149. The OH-PCBs were extracted from the microsomal incubations, derivatized with diazomethane and analyzed as the respective methoxylated (MeO-)PCB derivatives using selected columns. The 5-hydroxylated metabolites of PCBs 91, 95, 132, and 149 were the major metabolites, which is consistent with PCB's biotransformation by cytochrome P450 2B enzymes. All 5-hydroxylated metabolites displayed a clear, congener-specific enantiomeric enrichment. Overall, this study demonstrates for the first time that chiral PCBs, such as PCB 91, 95, 132, and 149, are enantioselectively metabolized to OH-PCBs by cytochrome P450 enzymes." @default.
• W2068092241 created "2016-06-24" @default.
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• W2068092241 date "2011-10-19" @default.
• W2068092241 modified "2023-09-23" @default.
• W2068092241 title "Gas Chromatographic Analysis with Chiral Cyclodextrin Phases Reveals the Enantioselective Formation of Hydroxylated Polychlorinated Biphenyls by Rat Liver Microsomes" @default.
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• W2068092241 doi "https://doi.org/10.1021/es2014727" @default.
• W2068092241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3216237" @default.
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